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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 898 - 905 (8page)
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초록· 키워드
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We aimed to identify the clinical variables associated with a better glucose-lowering response to the sodium glucose cotransporter 2 inhibitor ipragliflozin in people with type 2 diabetes mellitus (T2DM). We especially focused on urinary glucose excretion (UGE). This was a single-arm multicenter prospective study. A total of 92 people with T2DM aged 20 to 70 years with glycosylated hemoglobin (HbA1c) levels ≥7.0% and ≤9.5% were enrolled. Ipragliflozin (50 mg) was added to the background therapy for these people for 12 weeks. After 3 months treatment with ipragliflozin, the mean HbA1c levels were decreased from 7.6% to 6.9% and 62.0% of the people reached the HbA1c target of less than 7.0% (P<0.001). In addition, body weight, blood pressure, and lipid parameters were improved after ipragliflozin treatment (all P<0.001). The baseline HbA1c (r=0.66, P<0.001) and morning spot urine glucose to creatinine ratio (r=–0.30, P=0.001) were independently associated with the HbA1c reduction. Ipragliflozin treatment for 12 weeks improves glycemic control and other metabolic parameters. A higher HbA1c and lower UGE at baseline predicts a better glucose-lowering efficacy of ipragliflozin.
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등록된 정보가 없습니다.
참고문헌 (10)
참고문헌 신청
Monica Reddy RP / 2016 / SGLT2 inhibitors in the management of type 2 diabetes / Endocrine 53:364~372
정창희 / 2014 / A Novel Therapeutic Agent for Type 2 Diabetes Mellitus: SGLT2 Inhibitor / Diabetes and Metabolism Journal 38(4):261~273
Abe T / 2018 / Predictors of the response of HbA1c and body weight after SGLT2 inhibition / Diabetes Metab 44:172~174
Haneda M / 2016 / Influence of renal function on the 52-week efficacy and safety of the sodium glucose cotransporter 2 inhibitor luseogliflozin in Japanese patients with type 2 diabetes mellitus / Clin Ther 38:66~88.e20
Lim S / 2012 / Factors predicting therapeutic efficacy of combination treatment with sitagliptin and metformin in type 2 diabetic patients: the COSMETIC study / Clin Endocrinol(Oxf) 77:215~223
정창희 / 2014 / A Novel Therapeutic Agent for Type 2 Diabetes Mellitus: SGLT2 Inhibitor / Diabetes and Metabolism Journal 38(4):261~273
Abe T / 2018 / Predictors of the response of HbA1c and body weight after SGLT2 inhibition / Diabetes Metab 44:172~174
Haneda M / 2016 / Influence of renal function on the 52-week efficacy and safety of the sodium glucose cotransporter 2 inhibitor luseogliflozin in Japanese patients with type 2 diabetes mellitus / Clin Ther 38:66~88.e20
Lim S / 2012 / Factors predicting therapeutic efficacy of combination treatment with sitagliptin and metformin in type 2 diabetic patients: the COSMETIC study / Clin Endocrinol(Oxf) 77:215~223
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