지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 173 - 185 (13page)
이용수
초록· 키워드
오류제보하기
Background: Recent studies have shown that microRNAs (miRNAs) are involved in the process of cardiomyocyte apoptosis. We have previously reported that granulocyte-colony stimulating factor (G-CSF) ameliorated diastolic dysfunction and attenuated cardiomyocyte apoptosis in a rat model of diabetic cardiomyopathy. In this study, we hypothesized a regulatory role of cardiac miRNAs in the mechanism of the anti-apoptotic effect of G-CSF in a diabetic cardiomyopathy rat model. Methods: Rats were given a high-fat diet and low-dose streptozotocin injection and then randomly allocated to receive treatment with either G-CSF or saline. H9c2 rat cardiomyocytes were cultured under a high glucose (HG) condition to induce diabetic cardiomyopathy in vitro. We examined the extent of apoptosis, miRNA expression, and miRNA target genes in the myocardium and H9c2 cells. Results: G-CSF treatment significantly decreased apoptosis and reduced miR-34a expression in diabetic myocardium and H9c2 cells under the HG condition. G-CSF treatment also significantly increased B-cell lymphoma 2 (Bcl-2) protein expression as a target for miR-34a. In addition, transfection with an miR-34a mimic significantly increased apoptosis and decreased Bcl-2 luciferase activity in H9c2 cells. Conclusion: Our results indicate that G-CSF might have an anti-apoptotic effect through down-regulation of miR-34a in a diabetic cardiomyopathy rat model.
목차
등록된 정보가 없습니다.
참고문헌 (38)
참고문헌 신청
Bugger H / 2009 / Rodent models of diabetic cardiomyopathy / Dis Model Mech 2:454~466
Cai L / 2002 / Hyperglycemia-induced apoptosis in mouse myocardium : mitochondrial cytochrome C-mediated caspase-3 activation pathway / Diabetes 51:1938~1948
Zhou Q / 2014 / MicroRNAs in diabetic cardiomyopathy and clinical perspectives / Front Genet 5:185
Cheng Y / 2009 / MicroRNA-21 protects against the H(2)O(2)-induced injury on cardiac myocytes via its target gene PDCD4 / J Mol Cell Cardiol 47:5~14
Liu Z / 2015 / MicroRNA-150 protects the heart from injury by inhibiting monocyte accumulation in a mouse model of acute myocardial infarction / Circ Cardiovasc Genet 8:11~20
Cai L / 2002 / Hyperglycemia-induced apoptosis in mouse myocardium : mitochondrial cytochrome C-mediated caspase-3 activation pathway / Diabetes 51:1938~1948
Zhou Q / 2014 / MicroRNAs in diabetic cardiomyopathy and clinical perspectives / Front Genet 5:185
Cheng Y / 2009 / MicroRNA-21 protects against the H(2)O(2)-induced injury on cardiac myocytes via its target gene PDCD4 / J Mol Cell Cardiol 47:5~14
Liu Z / 2015 / MicroRNA-150 protects the heart from injury by inhibiting monocyte accumulation in a mouse model of acute myocardial infarction / Circ Cardiovasc Genet 8:11~20
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Effects of aerobic exercise on antioxidants in rat models with cardiomyopathy
Physical therapy rehabilitation science
2015 .01
-
Genetics of Cardiomyopathy: Clinical and Mechanistic Implications for Heart Failure
Korean Circulation Journal
2021 .10
-
Regulation of Colonic Mucosal MicroRNA Expression via Multiple Targets in Visceral Hypersensitivity Rats by Tongxieyaofang
Yonsei Medical Journal
2018 .01
-
건칠(乾漆)을 이용한 K562 만성 골수성 백혈병 세포주에서의 MicroRNA 발현 규명
대한본초학회지(본초분과학회지)
2019 .01
-
Upregulation of miR-27b Facilitates Apoptosis of TNF-α-Stimulated Fibroblast-Like Synoviocytes
Yonsei Medical Journal
2019 .01
-
Evaluation of immunocontraceptive vaccine composed of gonadotropin-releasing hormone conjugated with granulocyte-macrophage colony-stimulating factor in male rats
Korean Journal of Veterinary Research(대한수의학회지)
2017 .11
-
Recurrent fetal postpartum stress induced cardiomyopathy after normal vaginal delivery
고신대학교 의과대학 학술지
2017 .01
-
Analysis of miRNA expression in the trachea of Ri chicken infected with the highly pathogenic avian influenza H5N1 virus
Journal of Veterinary Science
2023 .09
-
Micro RNA 34a and Let-7a Expression in Human Breast Cancers is Associated with Apoptotic Expression Genes
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
제대혈 CD34 양성세포분획과 연관된 MicroRNA
대한수혈학회지
2019 .01
-
A novel panel of serum miR-21/miR-155/miR-365 as a potential diagnostic biomarker for breast cancer
Annals of Surgical Treatment and Research
2017 .02
-
Time-course changes in the expression levels of miR-122, -155, and -21 as markers of liver cell damage, inflammation, and regeneration in acetaminophen-induced liver injury in rats
Journal of Veterinary Science
2016 .03
-
The role of microRNAs in cell death pathways
Journal of Yeungnam Medical Science
2021 .01
-
Down Regulation of miR-34a and miR-143 May Indirectly Inhibit p53 in Oral Squamous Cell Carcinoma: a Pilot Study
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
MiR-484 Protects Rat Myocardial Cells from Ischemia-Reperfusion Injury by Inhibiting Caspase-3 and Caspase-9 during Apoptosis
Korean Circulation Journal
2020 .01
-
MiR-1246 Promotes Metastasis and Invasion of A549 Cells by Targeting GSK-3β–Mediated Wnt/β-Catenin Pathway
Cancer Research and Treatment
2019 .01
-
Molecular Mechanisms of Apoptosis and Roles in Cancer Development and Treatment
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Peripheral Signatures of Psychiatric Disorders: MicroRNAs
Clinical Psychopharmacology and Neuroscience
2017 .01
-
Expression of MicroRNA in Host Cells Infected with Helicobacter pylori
Gut and Liver
2017 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0