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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 699 - 710 (12page)
이용수
초록· 키워드
오류제보하기
Background: We sought to explore whether reduced pulmonary function is an independent risk factor for incident diabetes in Koreans. Methods: We conducted a prospective cohort study of pulmonary function as a risk factor for incident diabetes using 10-year follow- up data from 3,864 middle-aged adults from the Ansung cohort study in Korea. The incidence of diabetes was assessed using both oral glucose tolerance tests and glycosylated hemoglobin levels. Results: During 37,118 person-years of follow-up, 583 participants developed diabetes (incidence rate: 15.7 per 1,000 personyears). The mean follow-up period was 8.0±3.7 years. Forced vital capacity (FVC; % predicted) and forced expiratory volume in 1 second (FEV1; % predicted) were significantly correlated with incident diabetes in a graded manner after adjustment for sex, age, smoking, exercise, and metabolic parameters. The adjusted hazard ratio (HR) and confidence interval (CI) for diabetes were 1.408 (1.106 to 1.792) and 1.469 (1.137 to 1.897) in the first quartiles of FVC and FEV1, respectively, when compared with the highest quartile. Furthermore, the FVC of the lowest first and second quartiles showed a significantly higher 10-year panel homeostasis model assessment of insulin resistance index, with differences of 0.095 (95% CI, 0.010 to 0.018; P=0.028) and 0.127 (95% CI, 0.044 to 0.210; P=0.003), respectively, when compared to the highest quartiles. Conclusion: FVC and FEV1 are independent risk factors for developing diabetes in Koreans. Pulmonary factors are possible risk factors for insulin resistance and diabetes.
목차
등록된 정보가 없습니다.
참고문헌 (41)
참고문헌 신청
van den Borst B / 2010 / Pulmonary function in diabetes : a metaanalysis / Chest 138:393~406
Yeh HC / 2008 / Cross-sectional and prospective study of lung function in adults with type 2 diabetes : the Atherosclerosis Risk in Communities(ARIC)study / Diabetes Care 31:741~746
Eriksson KF / 1996 / Poor physical fitness, and impaired early insulin response but late hyperinsulinaemia, as predictors of NIDDM in middle-aged Swedish men / Diabetologia 39:573~579
Yeh HC / 2005 / Vital capacity as a predictor of incident type 2 diabetes : the Atherosclerosis Risk in Communities study / Diabetes Care 28:1472~1479
Engstrom G / 2002 / Risk of developing diabetes is inversely related to lung function : a population-based cohort study / Diabet Med 19:167~170
Yeh HC / 2008 / Cross-sectional and prospective study of lung function in adults with type 2 diabetes : the Atherosclerosis Risk in Communities(ARIC)study / Diabetes Care 31:741~746
Eriksson KF / 1996 / Poor physical fitness, and impaired early insulin response but late hyperinsulinaemia, as predictors of NIDDM in middle-aged Swedish men / Diabetologia 39:573~579
Yeh HC / 2005 / Vital capacity as a predictor of incident type 2 diabetes : the Atherosclerosis Risk in Communities study / Diabetes Care 28:1472~1479
Engstrom G / 2002 / Risk of developing diabetes is inversely related to lung function : a population-based cohort study / Diabet Med 19:167~170
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