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논문 기본 정보

자료유형
학술저널
저자정보
Choi Kwang Yong (Division of Pulmonary and Critical Care Medicine Department of Internal Medicine Seoul National University College of Medicine Seoul Metropolitan Government-Seoul National University Boramae Medical C) Lee Hyo Jin (Division of Pulmonary and Critical Care Medicine Department of Internal Medicine Seoul National University College of Medicine Seoul Metropolitan Government-Seoul National University Boramae Medical C) Lee Jung-Kyu (Division of Pulmonary and Critical Care Medicine Department of Internal Medicine Seoul National University College of Medicine Seoul Metropolitan Government-Seoul National University Boramae Medical C) Park Tae Yun (Division of Pulmonary and Critical Care Medicine Department of Internal Medicine Seoul National University College of Medicine Seoul Metropolitan Government-Seoul National University Boramae Medical C) Heo Eun Young (Division of Pulmonary and Critical Care Medicine Department of Internal Medicine Seoul National University College of Medicine Seoul Metropolitan Government-Seoul National University Boramae Medical C) Kim Deog Kyeom (Division of Pulmonary and Critical Care Medicine Department of Internal Medicine Seoul National University College of Medicine Seoul Metropolitan Government-Seoul National University Boramae Medical C) Lee Hyun Woo (Division of Pulmonary and Critical Care Medicine Department of Internal Medicine Seoul National University College of Medicine Seoul Metropolitan Government-Seoul National University Boramae Medical C)
저널정보
대한의학회 Journal of Korean Medical Science Journal of Korean Medical Science Vol.38 No.1
발행연도
2023.1
수록면
1 - 14 (14page)
DOI
10.3346/jkms.2023.38.e4

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Background: Forced expiratory volume in 1 second (FEV1)/forced vital capacity (FVC) naturally decreases with age; however, an excessive decline may be related with increased morbidity and mortality. This study aimed to evaluate the FEV1/FVC decline rate in the Korean general population and to identify whether rapid FEV1/FVC decline is a risk factor for obstructive lung disease (OLD) and all-cause and respiratory mortality. Methods: We evaluated individuals aged 40−69 years who underwent baseline and biannual follow-up spirometric assessments for up to 18 years, excluding those with airflow limitations at baseline. Based on the quartiles of the annual FEV1/FVC decline rate, the most negative FEV1/FVC change (1st quartile of annual FEV1/FVC decline rate) was classified as rapid FEV1/ FVC decline. We investigated the risk of progression to OLD and all-cause and respiratory mortality in individuals with rapid FEV1/FVC decline. Results: The annual FEV1/FVC decline rate in the eligible 7,768 patients was 0.32 percentage point/year. The incidence rate of OLD was significantly higher in patients with rapid FEV1/ FVC decline than in those with non-rapid FEV1/FVC decline (adjusted incidence rate, 2.119; 95% confidence interval [CI], 1.932–2.324). Rapid FEV1/FVC decline was an independent risk factor for all-cause mortality (adjusted hazard [HR], 1.374; 95% CI, 1.105–1.709) and respiratory mortality (adjusted HR, 1.353; 95% CI, 1.089–1.680). Conclusion: The annual FEV1/FVC decline rate was 0.32%p in the general population in Korea. The incidence rate of OLD and the hazards of all-cause and respiratory mortality were increased in rapid FEV1/FVC decliners.

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