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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 573 - 581 (9page)
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Purpose: To evaluate the usefulness of multiparametric magnetic resonance imaging (mpMRI) to avoid misclassification of patients with clinically significant prostate cancer (PCa) into active surveillance (AS). Materials and Methods: Patients with Gleason grade group (GG) 1 PCa on systematic biopsy who underwent mpMRI before radical prostatectomy (RP) were included. mpMRI and pathologic results were compared between the AS and NOT-AS candidates. Unfavorable disease was defined as the identification of T3-4 disease or GG upgrade in the RP specimen. We established an ideal cutoff Prostate Imaging Reporting and Data System (PI-RADS) score for predicting unfavorable disease, and analyzed the location of index lesions on mpMRI. Results: PI-RADS scores were not significantly different between AS candidates (n=64) and NOT-AS candidates (n=136; p=0.629). Among 64 AS candidates, GG upgrading and unfavorable disease were diagnosed after RP in 24 (37.5%) and 25 (39.1%) patients, respectively. The rate of unfavorable disease was greater for patients with a PI-RADS score of 5 (83.3%) than in those with a score ≤4 (34.5%; p=0.030). Moreover, most PI-RADS 5 lesions in AS candidates were located in the anterior half of the prostate, with GG upgrading on targeted biopsy in 75.0% of cases. Conclusions: Among the patients with GG 1 PCa, PI-RADS scores did not differ significantly between AS and NOT-AS candidates. Nonetheless, AS candidates with PI-RADS 5 lesions were diagnosed with unfavorable disease in >80% of RP specimens. Significant cancer located in the anterior half of the prostate including the transitional zone can be missed by systematic biopsy.
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참고문헌 (30)
참고문헌 신청
Bruinsma SM / 2016 / Active surveillance for prostate cancer : a narrative review of clinical guidelines / Nat Rev Urol 13:151~167
Morash C / 2015 / Active surveillance for the management of localized prostate cancer : guideline recommendations / Can Urol Assoc J 9:171~178
Klotz L / 2015 / Long-term follow-up of a large active surveillance cohort of patients with prostate cancer / J Clin Oncol 33:272~277
Tosoian JJ / 2020 / Active surveillance of grade group 1prostate cancer : long-term outcomes from a large prospective cohort / Eur Urol 77:675~682
Carlsson S / 2020 / Long-term outcomes of active surveillance for prostate cancer : the Memorial Sloan Kettering Cancer Center experience / J Urol 203:1122~1127
Morash C / 2015 / Active surveillance for the management of localized prostate cancer : guideline recommendations / Can Urol Assoc J 9:171~178
Klotz L / 2015 / Long-term follow-up of a large active surveillance cohort of patients with prostate cancer / J Clin Oncol 33:272~277
Tosoian JJ / 2020 / Active surveillance of grade group 1prostate cancer : long-term outcomes from a large prospective cohort / Eur Urol 77:675~682
Carlsson S / 2020 / Long-term outcomes of active surveillance for prostate cancer : the Memorial Sloan Kettering Cancer Center experience / J Urol 203:1122~1127
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