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논문 기본 정보

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학술저널
저자정보
Abolfazl Razzaghdoust (Shahid Beheshti University of Medical Sciences) Mahdi Ghajari (Shahid Beheshti University of Medical Sciences) Abbas Basiri (Shahid Beheshti University of Medical Sciences) Peyman Mohammadi Torbati (Shahid Beheshti University of Medical Sciences) Anya Jafari (Shahid Beheshti University of Medical Sciences) Mohammad-Reza Fattahi (Baqiyatallah University of Medical Sciences) Maryam Salahi (Shahid Beheshti University of Medical Sciences) Bahram Mofid (Shahid Beheshti University of Medical Sciences)
저널정보
대한비뇨기과학회 Investigative and Clinical Urology Investigative and Clinical Urology Vol.62 No.3
발행연도
2021.1
수록면
274 - 281 (8page)

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Purpose: A readily accessible biomarker to identify which patients with bladder cancer are more likely to respond to neoadjuvant chemotherapy (NAC) could help clinicians avoid unnecessary chemotherapy and prevent its subsequent complications in some patients. The primary objective of this study was to investigate the association of immunohistochemical markers of tumor subtype with response to NAC and survival of patients with muscle-invasive bladder cancer (MIBC). Materials and Methods: MIBC patients treated with NAC were retrospectively included. The tissue microarrays were assembled from transurethral resection of bladder tumor (TURBT) specimens and immunohistochemistry (IHC) was performed. The association of independent variables, including IHC markers, and clinical covariates with clinical complete response to NAC and with overall survival was assessed by using logistic regression and Cox proportional hazard regression analysis, respectively. Kaplan-Meier curves were plotted for different IHC-based tumor subtypes. Results: Data from 140 MIBC patients treated with NAC were retrospectively reviewed. A total of 63 patients with available TURBT specimens were eligible to be included in the analysis. Our results showed that the IHC signature of KRT5/6(+)/KRT20(−), as a combined marker of basal subtype, was the only covariate significantly associated with complete response to NAC (p=0.037). Moreover, we found no statistically significant differences in overall survival between different IHC-based subtypes (p=0.721). Conclusions: The IHC expression of KRT5/6 and KRT20, as a readily accessible combined marker, may help us to identify the patients most likely to benefit from chemotherapy. The clinical utility of this marker needs to be established in larger prospective studies.
#Biomarker #Bladder cancer #Chemotherapy #Immunohistochemistry

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참고문헌 (23)

참고문헌 신청
Siegel RL / 2020 / Cancer statistics, 2020 / CA Cancer J Clin 70:7~30 google schola Schardt J / 2019 / Forty years of cisplatin-based chemotherapy in muscle-invasive bladder cancer : are we understanding how, who and when? / World J Urol 37:1759~1765 google schola Rosenblatt R / 2012 / Pathologic downstaging is a surrogate marker for efficacy and increased survival following neoadjuvant chemotherapy and radical cystectomy for muscle-invasive urothelial bladder cancer / Eur Urol 61:1229~1238 google schola Grossman HB / 2003 / Neoadjuvant chemotherapy plus cystectomy compared with cystectomy alone for locally advanced bladder cancer / N Engl J Med 349:859~866 google schola International Collaboration of Trialists on behalf of the Medical Research Council Advanced Bladder Cancer Working Party / 2011 / International phase III trial assessing neoadjuvant cisplatin, methotrexate, and vinblastine chemotherapy for muscle-invasive bladder cancer : long-term results of the BA06 30894 trial / J Clin Oncol 29:2171~2177 google schola

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