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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 1,150 - 1,156 (7page)
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초록· 키워드
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We investigated trends in perioperative chemotherapy use, and determined factors associated with neoadjuvant chemotherapy (NAC) and adjuvant chemotherapy (AC) use in Korean patients with muscle- invasive bladder cancer (MIBC). We recruited 1,324 patients who had MIBC without nodal invasion or metastases and had undergone radical cystectomies (RC) between 2003 and 2013. The study’s cut-off time for AC was three months after surgery, and the study’s timespan was divided into three periods based on NAC use, namely, 2003-2005, 2006-2009, and 2010-2013. Complete remission was defined as histologically confirmed T0N0M0 after RC. NAC and AC were administered to 7.3% and 18.1% of the patients, respectively. The median time interval between completing NAC and undergoing RC was 32 days and the mean number of cycles was 3.2. The median time interval between RC and AC was 43 days and the mean number of cycles was 4.1. Gemcitabine and cisplatin were most frequently used in combination for NAC (49.0%) and AC (74.9%). NAC use increased significantly from 4.6% between 2003 and 2005 to 8.4% between 2010 and 2013 (P < 0.05), but AC use did not increase. Only 1.9% of patients received NAC and AC. Complete remission after NAC was achieved in 12 patients (12.5%). Multivariable modeling revealed that an advanced age, the earliest time period analyzed, and clinical tumor stage ≤ cT2 bladder cancer were negatively associated with NAC use (P < 0.05). While NAC use has slowly increased over time, it remains an underutilized therapeutic approach in Korean clinical practice.
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참고문헌 (21)
참고문헌 신청
Ferlay J / 2010 / Estimates of worldwide burden of cancer in 2008 : GLOBOCAN 2008 / Int J Cancer 127:2893~2917
Chavan S / 2014 / International variations in bladder cancer incidence and mortality / Eur Urol 66:59~73
Babjuk M / 2011 / EAU guidelines on non-muscle-invasive urothelial carcinoma of the bladder, the 2011 update / Eur Urol 59:997~1008
Stenzl A / 2011 / Treatment of muscle-invasive and metastatic bladder cancer: update of the EAU guidelines / Eur Urol 59:1009~1018
Colombel M / 2014 / Perioperative chemotherapy in muscle-invasive bladder cancer : overview and the unmet clinical need for alternative adjuvant therapy as studied in the MAGNOLIA trial / Eur Urol 65:509~511
Chavan S / 2014 / International variations in bladder cancer incidence and mortality / Eur Urol 66:59~73
Babjuk M / 2011 / EAU guidelines on non-muscle-invasive urothelial carcinoma of the bladder, the 2011 update / Eur Urol 59:997~1008
Stenzl A / 2011 / Treatment of muscle-invasive and metastatic bladder cancer: update of the EAU guidelines / Eur Urol 59:1009~1018
Colombel M / 2014 / Perioperative chemotherapy in muscle-invasive bladder cancer : overview and the unmet clinical need for alternative adjuvant therapy as studied in the MAGNOLIA trial / Eur Urol 65:509~511
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