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논문 기본 정보

자료유형
학술저널
저자정보
박세훈 (서울대학교) 이수진 (Seoul National University Hospital Seoul Republic of Korea) 김예림 (Department of Internal Medicine Keimyung University School of Medicine Kidney Institute Daegu Ko) 이연희 (Seoul National University Hospital Seoul Republic of Korea) 강민우 (Seoul National University Hospital Seoul Korea) Kyung Do Han (The Catholic University of Korea) 이하정 (Seoul National University College of Medicine) Jung Pyo Lee (SMG-SNU Boramae Medical Center) Kwon Wook Joo (Seoul National University) Chun Soo Lim (SMG-SNU Boramae Medical Center) Yon Su Kim (Department of Internal Medicine Seoul National University College of Medicine) Dong Ki Kim (Seoul National University)
저널정보
대한신장학회 Kidney Research and Clinical Practice Kidney Research and Clinical Practice Vol.39 No.2
발행연도
2020.1
수록면
180 - 191 (12page)

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Background: Metabolic syndrome (MetS) is linked to various chronic comorbidities, including chronic kidney disease (CKD). However, few large studies have addressed whether recovery from MetS is associated with reduction in the risks of such comorbidities. Methods: This nationwide population-based study in Korea screened 10,664,268 people who received national health screening ≥ 3 times between 2012 and 2016. Those with a history of major cardiovascular events or preexisting CKD were excluded. We classified study groups into four, according to the course of MetS state, as defined by the harmonizing criteria. The main study outcome was incidental CKD (estimated glomerular filtration rate < 60 mL/min/1.73 m2 which was persistent until the last health exams). The study outcomes were investigated using multivariable logistic regression analysis, which was adjusted for clinical variables and the previous severity of MetS. Results: Four study groups included 6,315,301 subjects: 4,537,869 people without MetS, 1,034,605 with chronic MetS, 438,287 who developed MetS, and 304,540 who recovered from preexisting MetS. Those who developed MetS demonstrated higher risk of CKD (adjusted odds ratio [OR], 1.26 [1.23-1.29]) than did those who did not develop MetS. In contrast, MetSrecovery was associated with decreased risk of CKD (adjusted OR, 0.84 [0.82-0.86]) than that in people with chronic MetS. Among the MetS components, change in hypertension was associated with the largest difference in CKD risk. Conclusion: Reducing or preventing MetS may reduce the burden of CKD on a population-scale. Clinicians should consider the clinical importance of altering MetS status for risk of CKD.
#Chronic kidney diseases #Diabetes mellitus #Dyslipidemia #Hypertension #Metabolic syndrome #Obesity

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참고문헌 (34)

참고문헌 신청
Sundström J / 2006 / Clinical value of the metabolic syndrome for long term prediction of total and cardiovascular mortality : prospective, population based cohort study / BMJ 332:878~882 google schola Jeppesen J / 2007 / Insulin resistance, the metabolic syndrome, and risk of incident cardiovascular disease : a population-based study / J Am Coll Cardiol 49:2112~2119 google schola Gami AS / 2007 / Metabolic syndrome and risk of incident cardiovascular events and death : a systematic review and meta-analysis of longitudinal studies / J Am Coll Cardiol 49:403~414 google schola Lakka HM / 2002 / The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men / JAMA 288:2709~2716 google schola Wannamethee SG / 2005 / Metabolic syndrome vs Framingham Risk Score for prediction of coronary heart disease, stroke, and type 2 diabetes mellitus / Arch Intern Med 165:2644~2650 google schola

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