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논문 기본 정보

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학술저널
저자정보
Kim Kipyo (Division of Nephrology and Hypertension Department of Internal Medicine Inha University College of) 백은지 (Seoul National University Bundang Hospital Seongnam Republic of Korea) Go Suryeong (Department of Internal Medicine Seoul National University Bundang Hospital Seongnam Korea.) Son Hyung Eun (Department of Internal Medicine Seoul National University Bundang Hospital Seongnam Korea.) Ryu Ji Young (Department of Internal Medicine Seoul National University Bundang Hospital Seongnam Korea.) 이용진 (Dankook University Hospital Dankook University College of Medicine Cheonan) Jeong Jong Cheol (Department of Internal Medicine Seoul National University Bundang Hospital Seoul National Universit) Kim Sejoong (Seoul National University Bundang Hospital) 진호준 (서울대학교)
저널정보
대한신장학회 Kidney Research and Clinical Practice Kidney Research and Clinical Practice Vol.40 No.2
발행연도
2021.1
수록면
220 - 230 (11page)

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Backgrounds: Recently, alternative surrogate endpoints such as a 30% or 40% decline in estimated glomerular filtration rate (eGFR) or eGFR slope over 2 to 3 years have been proposed for predicting renal outcomes. However, the impact of GFR estimation methods on the accuracy and effectiveness of surrogate markers is unknown. Methods: We retrospectively enrolled participants in health screening programs at three hospitals from 1995 to 2009. We defined two different participant groups as YR1 and YR3, which had available 1-year or 3-year eGFR values along with their baseline eGFR levels. We compared the effectiveness of eGFR percentage change or slope to estimate end-stage renal disease (ESRD) risk according to two estimating equations (modified Modification of Diet in Renal Disease equation [eGFRm] and Chronic Kidney Disease-Epidemiology Collaboration (CKD-EPI) equation [eGFRc]) for GFR. Results: In the YR1 and YR3 groups, 9,971 and 10,171 candidates were enrolled and ESRD incidence during follow-up was 0.26% and 0.19%, respectively. The eGFR percentage change was more effective than eGFR slope in estimating ESRD risk, regardless of the method of estimation. A 40% of decline in eGFR was better than 30%, and a 3-year baseline period was better than a 1-year period for prediction accuracy. Although some diagnostic indices from the CKD-EPI equation were better, we found no significant differences in the discriminative ability and hazard ratios for incident ESRD between eGFRc and eGFRm in either eGFR percentage change or eGFR slope. Conclusion: There were no significant differences in the prediction accuracy of GFR percentage change or eGFR slope between eGFRc and eGFRm in the general population.
#Chronic kidney disease #End-stage renal disease #Glomerular filtration rate #Renal endpoint #Surrogate endpoint

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참고문헌 (29)

참고문헌 신청
Go AS / 2004 / Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization / N Engl J Med 351:1296~1305 google schola Chronic Kidney Disease Prognosis Consortium / 2010 / Association of estimated glomerular fil tration rate and albuminuria with all-cause and cardiovascular mortality in general population cohorts: a collaborative meta-analysis / Lancet 375:2073~2081 google schola Palmer SC / 2011 / Trial quality in ne"phrology : how are we measuring up / Am J Kidney Dis 58:335~337 google schola Ferguson TW / 2016 / Change in estimated glo"merular filtration rate and outcomes in chronic kidney disease / Curr Opin Nephrol Hypertens 25:240~244 google schola Weldegiorgis M / 2015 / Renal end points in clinical trials of kidney disease / Curr Opin Nephrol Hypertens 24:284~289 google schola

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