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논문 기본 정보

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Alfano Gaetano (University of Modena and Reggio Emilia Modena) Ferrari Annachiara (University of Modena and Reggio Emilia Modena) Fontana Francesco (University Hospital of Modena Modena Italy) Mori Giacomo (University Hospital of Modena Modena Italy) Ligabue Giulia (University of Modena and Reggio Emilia Modena) Giovanella Silvia (University of Modena and Reggio Emilia Modena) Magistroni Riccardo (University of Modena and Reggio Emilia Modena) Meschiari Marianna (University Hospital of Modena Modena Italy) Franceschini Erica (University Hospital of Modena Modena Italy) Menozzi Marianna (University Hospital of Modena Modena Italy) Cuomo Gianluca (University Hospital of Modena Modena Italy) Orlando Gabriella (University Hospital of Modena Modena Italy) Santoro Antonella (University Hospital of Modena Modena Italy) Di Gaetano Margherita (University Hospital of Modena Modena Italy) Puzzolante Cinzia (University Hospital of Modena Modena Italy) Carli Federica (University Hospital of Modena Modena Italy) Bedini Andrea (University Hospital of Modena Modena Italy) Milic Jovana (University of Modena and Reggio Emilia Modena Italy) Mussini Cristina (University Hospital of Modena Modena Italy) Cappelli Gianni (University of Modena and Reggio Emilia Modena) Guaraldi Giovanni (University Hospital of Modena Modena Italy)
저널정보
대한신장학회 Kidney Research and Clinical Practice Kidney Research and Clinical Practice Vol.40 No.2
발행연도
2021.1
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231 - 240 (10page)

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Background: The prognostic value of within-day sCr variation serum creatinine variation is unknown in the setting of the novel coronavirus disease 2019 (COVID-19). We evaluated the prognostic significance of 24-hour serum creatinine variation in COVID-19 patients. Methods: A monocentric retrospective analysis was conducted in COVID-19 patients not admitted to the intensive care unit. Three groups were subdivided based on 24 hours serum creatinine variation from admission. In the stable kidney function group, 24-hour serum creatinine variation ranged from +0.05 to –0.05 mg/dL; in the decreased kidney function group, 24-hour serum creatinine variation was >0.05 mg/dL; in the improved kidney function group, 24-hour serum creatinine variation was <–0.05 mg/dL. Results: The study population included 224 patients with a median age of 66.5 years and a predominance of males (72.3%). Within 24 hours of admission, renal function remained stable in 37.1% of the subjects, whereas it displayed improved and deteriorated patterns in 45.5% and 17.4%, respectively. Patients with decreased kidney function were older and had more severe COVID-19 symptoms than patients with stable or improved kidney function. About half of patients with decreased kidney function developed an episode of acute kidney injury (AKI) during hospitalization. Decreased kidney function was significantly associated with AKI during hospitalization (hazard ratio [HR], 4.6; 95% confidence interval [CI], 1.9–10.8; p < 0.001) and was an independent risk factor for 30-day in-hospital mortality (HR, 5.5; 95% CI, 1.1–28; p = 0.037). Conclusion: COVID-19 patients with decreased kidney function within 24 hours of admission were at high risk of AKI and 30-day in-hospital mortality
#: Acute kidney injury #Biomarkers #Coronavirus #Kidney #Creatinine #Mortality

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참고문헌 (22)

참고문헌 신청
Yuki K / 2020 / COVID-19 pathophysiology : a review / Clin Immunol 215:108427 google schola Hirsch JS / 2020 / Acute kidney injury in patients hospitalized with COVID-19 / Kidney Int 98:209~218 google schola Ronco C / 2020 / Management of acute kidney in"jury in patients with COVID-19 / Lancet Respir Med 8:738~742 google schola Huang C / 2020 / Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China / Lancet 395:497~506 google schola Chen N / 2020 / Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China : a descriptive study / Lancet 395:507~513 google schola

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