지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한응급의학회 Clinical and Experimental Emergency Medicine Clinical and Experimental Emergency Medicine Vol.7 No.3
- 발행연도
- 2020.1
- 수록면
- 161 - 169 (9page)
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초록· 키워드
오류제보하기
Objective No studies have evaluated the diagnostic value of ischemia-modified albumin (IMA) for the early detection of sepsis/septic shock in patients presenting to the emergency department (ED). We aimed to assess the usefulness of IMA in diagnosing sepsis/septic shock in the ED. Methods This retrospective, observational study analyzed IMA, lactate, high sensitivity C-reactive protein, and procalcitonin levels measured within 1 hour of ED arrival. Patients with suspected infection meeting at least two systemic inflammatory response syndrome criteria were included and classified into the infection, sepsis, and septic shock groups using Sepsis-3 definitions. Areas under the receiver operating characteristic curves (AUCs) with 95% confidence intervals (CIs) and multivariate logistic regression were used to determine diagnostic performance. Results This study included 300 adult patients. The AUC (95% CI) of IMA levels (cut-off ≥85.5 U/mL vs. ≥87.5 U/mL) was higher for the diagnosis of sepsis than for that of septic shock (0.729 [0.667–0.791] vs. 0.681 [0.613–0.824]) and was higher than the AUC of procalcitonin levels (cut-off ≥1.58 ng/mL, 0.678 [0.613–0.742]) for the diagnosis of sepsis. When IMA and lactate levels were combined, the AUCs were 0.815 (0.762–0.867) and 0.806 (0.754–0.858) for the diagnosis of sepsis and septic shock, respectively. IMA levels independently predicted sepsis (odds ratio, 1.05; 95% CI, 1.00–1.09; P=0.029) and septic shock (odds ratio, 1.07; 95% CI, 1.02–1.11; P=0.002). Conclusion Our findings indicate that IMA levels are a useful biomarker for diagnosing sepsis/septic shock early, and their combination with lactate levels can enhance the predictive power for early diagnosis of sepsis/septic shock in the ED.
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등록된 정보가 없습니다.
참고문헌 (41)
참고문헌 신청
Dellinger RP / 2004 / Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock / Crit Care Med 32:858~873
Dellinger RP / 2008 / Surviving Sepsis Campaign : international guidelines for management of severe sepsis and septic shock : 2008 / Intensive Care Med 34:17~60
Dellinger RP / 2013 / Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock, 2012 / Intensive Care Med 39:165~228
Rhodes A / 2017 / Surviving Sepsis Campaign : international guidelines for management of sepsis and septic shock : 2016 / Crit Care Med 45:486~552
Martin GS / 2012 / Sepsis, severe sepsis and septic shock: changes in incidence, pathogens and outcomes / Expert Rev Anti Infect Ther 10:701~706
Dellinger RP / 2008 / Surviving Sepsis Campaign : international guidelines for management of severe sepsis and septic shock : 2008 / Intensive Care Med 34:17~60
Dellinger RP / 2013 / Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock, 2012 / Intensive Care Med 39:165~228
Rhodes A / 2017 / Surviving Sepsis Campaign : international guidelines for management of sepsis and septic shock : 2016 / Crit Care Med 45:486~552
Martin GS / 2012 / Sepsis, severe sepsis and septic shock: changes in incidence, pathogens and outcomes / Expert Rev Anti Infect Ther 10:701~706
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