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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 108 - 116 (9page)
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초록· 키워드
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Background and Objectives: The immunomodulatory effects and mechanism of probiotics in allergic airway disease are largely unknown. We studied whether Bacillus clausii (BC), a probiotic derived from mudflats, had anti-allergic effects and compared the results with those of Lactobacillus paracasei (LP). We also examined whether the anti-allergic mechanisms of probiotics are associated with hypoxia signaling. Materials and Method: Forty-two BALB/c mice were randomly assigned to six experimental groups: controls, ovalbumin (OVA)-induced mice for inducing asthma, and OVA-induced mice that were orally administered LP or BC, at 1×109 or 5×109 CFU/mL each. We performed differential cell count testing on bronchoalveolar lavage fluid (BALF), lung histopathology, serum totals and OVA-specific IgE and IgG1 assessments, Th2 cytokine titers (IL-4, IL-5) in BALF and pulmonary parenchyma, quantitative PCR for heme oxygenase (HO)-1 and Hif-1α, and immunohistochemistry. Results: Compared to the OVA group mice, OVA-sensitized mice treated with LP or BC showed significantly reduced numbers of eosinophils and neutrophils in the BALF (p<0.05). Both probiotics also significantly reduced pulmonary inflammation and eosinophil infiltration. Mice in the LP or BC group had a substantially lower titer of IL-4 and IL-5 in BALF, and decreased IL-4 and IL-5 expression in the lung parenchyma. Real-time PCR and immunohistochemistry showed that both LP and BC could significantly suppress HO-1 and Hif-1α expression in asthmatic mice (p<0.05). Conclusion: BC can attenuate murine allergic asthma by regulating HIF-1α signaling, and its anti-allergic effect is comparable to that of LP.
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참고문헌 (21)
참고문헌 신청
Fulkerson PC / 2013 / Targeting eosinophils in allergy, inflammation and beyond / Nat Rev Drug Discov 12:117~129
Holgate ST / 2011 / Pathophysiology of asthma: what has our current understanding taught us about new therapeutic approaches? / J Allergy Clin Immunol 128:495~505
Wills-Karp M / 2001 / The germless theory of allergic disease : revisiting the hygiene hypothesis / Nat Rev Immunol 1:69~75
Christodoulopoulos P / 2000 / Molecular pathology of allergic disease. II: Upper airway disease / J Allergy Clin Immunol 105:211~223
Otani IM / 2013 / Anti-IL-5 therapy reduces mast cell and IL-9 cell numbers in pediatric patients with eosinophilic esophagitis / J Allergy Clin Immunol 131:1576~1582
Holgate ST / 2011 / Pathophysiology of asthma: what has our current understanding taught us about new therapeutic approaches? / J Allergy Clin Immunol 128:495~505
Wills-Karp M / 2001 / The germless theory of allergic disease : revisiting the hygiene hypothesis / Nat Rev Immunol 1:69~75
Christodoulopoulos P / 2000 / Molecular pathology of allergic disease. II: Upper airway disease / J Allergy Clin Immunol 105:211~223
Otani IM / 2013 / Anti-IL-5 therapy reduces mast cell and IL-9 cell numbers in pediatric patients with eosinophilic esophagitis / J Allergy Clin Immunol 131:1576~1582
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