지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한소화관운동학회(현 대한소화기능성질환.운동학회) Journal of Neurogastroenterology and Motility (JNM) Journal of Neurogastroenterology and Motility (JNM) Vol.25 No.2
- 발행연도
- 2019.1
- 수록면
- 189 - 204 (16page)
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초록· 키워드
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The internal anal sphincter (IAS) plays an important role in the maintenance of fecal continence since it generates tone and is responsible for > 70% of resting anal pressure. During normal defecation the IAS relaxes. Historically, tone generation in gastrointestinal muscles was attributed to mechanisms arising directly from smooth muscle cells, ie, myogenic activity. However, slow waves are now known to play a fundamental role in regulating gastrointestinal motility and these electrical events are generated by the interstitial cells of Cajal. Recently, interstitial cells of Cajal, as well as slow waves, have also been identified in the IAS making them viable candidates for tone generation. In this review we discuss four different mechanisms that likely contribute to tone generation in the IAS. Three of these involve membrane potential, L-type Ca2+ channels and electromechanical coupling (ie, summation of asynchronous phasic activity, partial tetanus, and window current), whereas the fourth involves the regulation of myofilament Ca2+ sensitivity. Contractile activity in the IAS is also modulated by sympathetic motor neurons that significantly increase tone and anal pressure, as well as inhibitory motor neurons (particularly nitrergic and vasoactive intestinal peptidergic) that abolish contraction and assist with normal defecation. Alterations in IAS motility are associated with disorders such as fecal incontinence and anal fissures that significantly decrease the quality of life. Understanding in greater detail how tone is regulated in the IAS is important for developing more effective treatment strategies for these debilitating defecation disorders.
목차
등록된 정보가 없습니다.
참고문헌 (145)
참고문헌 신청
Rao SS / 2011 / What is necessary to diagnose constipation? / Best Pract Res Clin Gastroenterol 25:127~140
Bharucha A / 2004 / Pathophysiology of the enteric nervous system: a basis for understanding functional diseases / Blackwell Publishing :161~175
Lestar B / 1989 / The composition of anal basal pressure. An in vivo and in vitro study in man / Int J Colorectal Dis 4:118~122
Brading AF / 2006 / Mechanisms controlling normal defecation and the potential effects of spinal cord injury / Prog Brain Res 152:345~358
Whitehead WE / 2002 / Fecal incontinence : a neglected area of gastroenterology / Gastroenterology 122:5
Bharucha A / 2004 / Pathophysiology of the enteric nervous system: a basis for understanding functional diseases / Blackwell Publishing :161~175
Lestar B / 1989 / The composition of anal basal pressure. An in vivo and in vitro study in man / Int J Colorectal Dis 4:118~122
Brading AF / 2006 / Mechanisms controlling normal defecation and the potential effects of spinal cord injury / Prog Brain Res 152:345~358
Whitehead WE / 2002 / Fecal incontinence : a neglected area of gastroenterology / Gastroenterology 122:5
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