Analgesic effect of structured anal skin care for perianal dermatitis after low anterior resection in the rectal cancer patients: prospective, single-center, open-label, therapeutic confirmatory, randomized clinical trial

Gyung Mo Son; In Young Lee; Mi Sook Yun; Jung-Hea Youn; Hong Min An; Kyung Hee Kim; Seung Mi Yeo; Bokyung Ku; Myeong Suk Kwon; Kun Hyung Kim

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저자정보: Gyung Mo Son (Pusan National University School of Medicine) In Young Lee (Pusan National University Yangsan Hospital) Mi Sook Yun (Pusan National University Yangsan Hospital) Jung-Hea Youn (Pusan National University Yangsan Hospital) Hong Min An (Pusan National University School of Medicine) Kyung Hee Kim (Pusan National University School of Medicine) Seung Mi Yeo (Pusan National University Yangsan Hospital) Bokyung Ku (Pusan National University Yangsan Hospital) Myeong Suk Kwon (Silla University) Kun Hyung Kim (Pusan National University Korean Medicine Hospital)

저널정보: 대한외과학회 Annals of Surgical Treatment and Research Annals of Surgical Treatment and Research Vol.103 No.6

발행연도: 2022.12

수록면: 360 - 371 (12page)

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2022

Analgesic effect of structured anal skin care for perianal dermatitis after low anterior resection in the rectal cancer patients: prospective, single-center, open-label, therapeutic confirmatory, randomized clinical trial

Gyung Mo Son , In Young Lee , Mi Sook Yun 외 7명 Annals of Surgical Treatment and Research 2022.12 학술저널

Analgesic effect of active anal skin care for perianal dermatitis after low anterior resection in the rectal cancer patients; Prospective randomized clinical trial

Gyung Mo Son 대한임상종양학회 학술대회지 2022.02 학술대회자료

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Purpose: This prospective, single-center, open-label, therapeutic confirmatory, randomized clinical trial aimed to assess the alleviation of anal pain by applying structured anal skin care including skin protectants in rectal cancer patients with low anterior resection syndrome (LARS) combined with anal pain.
Methods: From December 2017 to May 2020, 42 patients with LARS (scores of ≥21) and anal pain (visual analogue scale [VAS] score of ≥3) were randomly assigned and observed for 4 weeks. The conventional treatment consisted of dietary management, sitz baths, prohibition of anal scrubbing, loperamide, and dioctahedral smectite. In the anal care group, cleanser, barrier cream, and barrier spray were applied to the anal skin after defecation following the conventional treatment. The primary outcome was analgesic effect on anal pain after 2 weeks of structured treatment (anal care group) or conventional (control group). The cutoff for analgesic effect was a decrease in the anal pain score (VAS score of ≥2 or ≥30% reduction).
Results: As a primary outcome, the analgesic effect was significantly higher in the anal care group (P = 0.034). The incontinence-associated dermatitis skin condition score was significantly improved in the anal care group than control group after 4 weeks (P = 0.023). There were no significant differences in LARS scores and quality of life scores between 2 groups.
Conclusion: Structured anal skin care has a significant analgesic effect in reducing anal pain and improving anal skin conditions in patients with LARS after rectal cancer surgery.

#Fecal incontinence #Irritant dermatitis #Pain management #Rectal neoplasms #Skin care

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