지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 624 - 628 (5page)
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초록· 키워드
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Treatment of perianal and vulvar extramammary Paget disease (EMPD), rare intraepithelial malignancies, is often challenging because of its potential to spread into the anal canal.
However, there is still no consensus regarding the optimal resection margin within the anal canal. Between 2004 and 2014, six patients (three with perianal EMPD and three with vulvar EMPD) in which the spread of Paget cells into the anal canal was highly suspected were referred to our department.
To evaluate the disease extent within the anal canal, preoperative mapping biopsy of the anal canal was performed in five out of six patients. Two patients were positive for Paget cells within the anal canal (one at the dentate line and the other at 0.5 cm above the dentate line), whereas in three patients, Paget cell were present only in the skin of the anal verge. Using 1 cm margin within the anal canal from the positive biopsy sites, we performed anal-preserving wide local excision (WLE), and negative resection margins within the anal canal were confirmed in all five patients. The remaining one patient with perianal EMPD did not undergo mapping biopsy of the anal canal because preoperative colonoscopy revealed that the Paget cells had spread into the lower rectum.
Therefore, WLE with abdominoperineal resection was performed. During the median follow-up period of 37.3 months, no local recurrence was observed in all patients.
Our small case series suggest the usefulness of mapping biopsy of the anal canal for the treatment of perianal and vulvar EMPD.
목차
등록된 정보가 없습니다.
참고문헌 (15)
참고문헌 신청
Kanitakis J / 2007 / Mammary and extramammary Paget's disease / J Eur Acad Dermatol Venereol 21:581~590
Lloyd J. / 2000 / Mammary and extramammary Paget's disease / J Clin Pathol 53:742~749
Minicozzi A. / 2010 / Perianal Paget's disease : presentation of six cases and literature review / Int J Colorectal Dis 25:1~7
Kyriazanos ID. / 2011 / Extra-mammary Paget's disease of the perianal region: a review of the literature emphasizing the operative management technique / Surg Oncol 20:e61~e71
Chan JY. / 2012 / Extramammary Paget's disease: 20 years of experience in chinese population / Int J Surg Oncol
Lloyd J. / 2000 / Mammary and extramammary Paget's disease / J Clin Pathol 53:742~749
Minicozzi A. / 2010 / Perianal Paget's disease : presentation of six cases and literature review / Int J Colorectal Dis 25:1~7
Kyriazanos ID. / 2011 / Extra-mammary Paget's disease of the perianal region: a review of the literature emphasizing the operative management technique / Surg Oncol 20:e61~e71
Chan JY. / 2012 / Extramammary Paget's disease: 20 years of experience in chinese population / Int J Surg Oncol
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