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논문 기본 정보

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학술저널
저자정보
Shinta Mizuno (Keio University School of Medicine) Keiko Ono (Keio University School of Medicine) Yohei Mikami (Keio University School of Medicine) Makoto Naganuma (Keio University School of Medicine) Tomohiro Fukuda (Keio University School of Medicine) Kazuhiro Minami (Keio University School of Medicine) Tatsuhiro Masaoka (Keio University School of Medicine) Soichiro Terada (Edogawa Hospital) Takeshi Yoshida (Saitama Medical Center) Keiichiro Saigusa (Tokyo Saiseikai Central Hospital) Norimichi Hirahara (Keio University School of Medicine) Hiroaki Miyata (Keio University School of Medicine) Wataru Suda (RIKEN Center for Integrative Medical Sciences) Masahira Hattori (RIKEN Center for Integrative Medical Sciences) Takanori Kanai (Keio University School of Medicine)
저널정보
대한장연구학회 Intestinal research Intestinal research Vol.18 No.1
발행연도
2020.1
수록면
69 - 78 (10page)

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Background/Aims: 5-Aminosalicylic acid (ASA) causes intolerance reactions in some patients. This study was performed to examine the prognosis of patients with ulcerative colitis (UC) and 5-ASA intolerance, and to evaluate the potential interaction between 5-ASA intolerance and the intestinal microbiota. Methods: We performed a retrospective cohort study of patients with UC who visited participating hospitals. The primary endpoint was to compare the incidence of hospitalization within 12 months between the 5-ASA intolerance group and the 5-ASA tolerance group. The secondary endpoint was to compare the risk of adverse clinical outcomes after the start of biologics between the 2 groups. We also assessed the correlation between 5-ASA intolerance and microbial change in an independently recruited cohort of patients with UC. Results: Of 793 patients, 59 (7.4%) were assigned to the 5-ASA intolerance group and 734 (92.5%) were assigned to the 5-ASA tolerance group. The admission rate and incidence of corticosteroid use were significantly higher in the intolerance than tolerance group (P<0.001). In 108 patients undergoing treatment with anti-tumor necrosis factor biologics, 5-ASA intolerance increased the incidence of additional induction therapy after starting biologics (P<0.001). The 5-ASA intolerance group had a greater abundance of bacteria in the genera Faecalibacterium, Streptococcus, and Clostridium than the 5-ASA tolerance group (P<0.05). Conclusions: In patients with UC, 5-ASA intolerance is associated with a risk of adverse clinical outcomes and dysbiosis. Bacterial therapeutic optimization of 5-ASA administration may be important for improving the prognosis of patients with UC.
#5-Aminosalicylic acid #Colitis #ulcerative #Prognosis #Dysbiosis

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참고문헌 (52)

참고문헌 신청
Danese S / 2011 / Ulcerative colitis / N Engl J Med 365:1713~1725 google schola Almario CV / 2018 / Optimizing selection of biologics in inflammatory bowel disease : development of an online patient decision aid using conjoint analysis / Am J Gastroenterol 113:58~71 google schola White JR / 2018 / Review article : novel oral-targeted therapies in inflammatory bowel disease / Aliment Pharmacol Ther 47:1610~1622 google schola Kaplan GG / 2012 / Decreasing colectomy rates for ulcerative colitis : a population-based time trend study / Am J Gastroenterol 107:1879~1887 google schola Vester-Andersen MK / 2014 / Disease course and surgery rates in inflammatory bowel disease: a population-based, 7-year follow-up study in the era of immunomodulating therapy / Am J Gastroenterol 109:705~714 google schola

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