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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 157 - 165 (9page)
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초록· 키워드
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Antipsychotics have been utilized as the standard treatment for schizophrenia regardless of illness phase where antipsychotic monotherapy (APM) is routinely recommended as the gold standard rather than antipsychotic polypharmacy (APP). However, approximately 20 to 40% of patients with schizophrenia do not respond to APM based on randomized controlled clinical trials and large practical clinical trials indicating that the subgroup of patients with schizophrenia would need differential treatment approaches beyond traditional treatment strategies such as APM. Numerous studies have supported the use of APP in particular for patients with certain clinical situations including: failure to show efficacy or tolerability from treatment with APM, need for different treatment for targeting specific symptom domains, severe illness, failure to treatment with clozapine, skepticism about following treatment guidelines, or cross titration periods. Furthermore, recent large cohort studies and practical clinical trials have proposed more benefits of APP rather than APM in terms of rehospitalization, mortality, and specific symptoms. APP has recently become more widely utilized and recognized as one of the next treatment strategies to clinicians for patients with schizophrenia. Some experts have already proposed the revision of treatment guidelines incorporating APP as evidence-based treatment option for certain patients with schizophrenia. Taken together, APP now deserves an evidence-based and acceptable treatment strategy, not an empirical or preferential treatment approach for treatment of schizophrenia in contemporary clinical practice.
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참고문헌 (67)
참고문헌 신청
배치운 / 2020 / Effectiveness and Tolerability of Switching to Aripiprazole Once Monthly from Antipsychotic Polypharmacy and/or Other Long Acting Injectable Antipsychotics for Patients with Schizophrenia in Routine Practice: A Retrospective, Observation Study / Clinical Psychopharmacology and Neuroscience 18(1):153~158
Wang SM / 2017 / Investigational dopamine antagonists for the treatment of schizophrenia / Expert Opin Investig Drugs 26:687~698
Konstantinos N. Fountoulakis / 2020 / One-year Outcome of First vs. Later Episode Schizophrenia: A Real-world Naturalistic Study / Clinical Psychopharmacology and Neuroscience 18(3):434~444
Yujin Lee / 2019 / Medication Adherence Using Electronic Monitoring in Severe Psychiatric Illness: 4 and 24 Weeks after Discharge / Clinical Psychopharmacology and Neuroscience 17(2):288~296
Pae CU / 2013 / Role of the cholinesterase inhibitors in the treatment of schizophrenia / Expert Opin Investig Drugs 22:293~298
Wang SM / 2017 / Investigational dopamine antagonists for the treatment of schizophrenia / Expert Opin Investig Drugs 26:687~698
Konstantinos N. Fountoulakis / 2020 / One-year Outcome of First vs. Later Episode Schizophrenia: A Real-world Naturalistic Study / Clinical Psychopharmacology and Neuroscience 18(3):434~444
Yujin Lee / 2019 / Medication Adherence Using Electronic Monitoring in Severe Psychiatric Illness: 4 and 24 Weeks after Discharge / Clinical Psychopharmacology and Neuroscience 17(2):288~296
Pae CU / 2013 / Role of the cholinesterase inhibitors in the treatment of schizophrenia / Expert Opin Investig Drugs 22:293~298
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