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논문 기본 정보

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저자정보
Seung Joo Kang (Department of Internal Medicine Seoul National University Hospital Gangnam Center) Hye-Kyung Jung (Department of Internal Medicine Ewha Womans University College of Medicine Seoul Korea) Yong Chan Lee (Department of Internal Medicine Yonsei University College of Medicine Seoul Korea) Hyo-Joon Yang (Department of Internal Medicine Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine) Seon-Young Park (Department of Internal Medicine Chonnam National University Medical School Gwangju Korea) Cheol Min Shin (Department of Internal Medicine Seoul National University Bundang Hospital) Sung Eun Kim (Department of Internal Medicine Kosin University College of Medicine) Hyun Chul Lim (Department of Internal Medicine Yongin Severance Hospital Yonsei University College of Medicine Yon) Jie-Hyun Kim (Department of Internal Medicine Gangnam Severance Hospital Yonsei University College of Medicine) Su Youn Nam (Division of Gastroenterology Department of Internal Medicine School of Medicine Kyungpook National) Woon Geon Shin (Department of Internal Medicine Hallym University College of Medicine) Jae Myung Park (Department of Gastric Cancer Centre Seoul St. Mary's Hospital The Catholic University of Korea) Il Ju Choi (National Cancer Center) Jae Gyu Kim (Departments of Internal Medicine Chung-Ang University College of Medicine Seoul Korea) Miyoung Choi (National Evidence-based Healthcare Collaborating Agency) Korean College of Helicobacter and Upper Gastrointesinal Research (Korean College of Helicobacter and Upper Gastrointesinal Research)
저널정보
대한상부위장관 헬리코박터학회 Korean Journal of Helicobacter Upper Gastrointestinal Research Korean Journal of Helicobacter Upper Gastrointestinal Research Vol.21 No.1
발행연도
2021.1
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35 - 47 (13page)

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Background/Aims: Standard triple therapy, including a proton pump inhibitor, clarithromycin, and amoxicillin, has been recommended as the first-line for Helicobacter pylori infection. However, the eradication rate of standard triple therapy has declined over the past years because of the increasing resistance to clarithromycin in Korea. We analyzed the eradication rates and the 10-year change in the eradication rates in Korea. Methods: PubMed, EMBASE, the Cochrane Library, and KoreaMed were searched for studies published between January 2007 and June 2018. The pooled eradication rates and their 95% CIs were estimated using a random-effect logistic regression model. Results: Twenty-six randomized controlled studies on standard triple therapy conducted in Korea were selected. The intention- to-treat (ITT) and per protocol analyses showed pooled eradication rates of standard triple therapy of 71.6% (95% CI, 69.9~73.3%) and 79.6% (95% CI, 76.6~82.2%), respectively. The eradication rate decreased with time. The ITT analysis showed that the 14-day therapy (78.1% [95% CI, 75.2~80.7%]) had significantly higher eradication rates than the 7-day therapy (70.0% [95% CI, 68.5~71.4%]) (P<0.01). Conclusions: These results suggest that the eradication rate of standard triple therapy, as the first-line therapy, has shown an unacceptable decrease. The eradication rate increased when the duration of therapy was increased to 14 days, but it was not satisfactory. Therefore, other treatment regimens or therapies based on susceptibility tests should be considered for the first-line therapy.
#Clarithromycin #Disease eradication #Helicobacter pylori #Meta-analysis

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참고문헌 (40)

참고문헌 신청
Hooi JKY / 2017 / Global prevalence of Helicobacter pylori infection: systematic review and meta-analysis / Gastroenterology 153:420~429 google schola Malfertheiner P / 2017 / Management of Helicobacter pylori infection-the Maastricht V/Florence consensus report / Gut 66:6~30 google schola Lim SH / 2013 / Prevalence and risk factors of Helicobacter pylori infection in Korea : nationwide multicenter study over 13 years / BMC Gastroenterol 13:104 google schola 김상균 / 2013 / 한국인 헬리코박터 파일로리 감염의 진단과 치료 임상 진료지침 개정안 2013 / 대한소화기학회지 62(1):3~26 google schola Venerito M / 2013 / Meta-analysis of bismuth quadruple therapy versus clarithromycin triple therapy for empiric primary treatment of Helicobacter pylori infection / Digestion 88:33~45 google schola

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