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논문 기본 정보

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저자정보
Sung Eun Kim (Department of Internal Medicine Kosin University College of Medicine) Hye-Kyung Jung (Department of Internal Medicine Ewha Medical Research Institute Ewha Womans University College of M) Seung Joo Kang (Department of Internal Medicine Seoul National University Hospital Gangnam Center) Yong Chan Lee (Department of Internal Medicine Yonsei University College of Medicine Seoul Korea) Hyo-Joon Yang (Department of Internal Medicine Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine) Seon-Young Park (Department of Internal Medicine Chonnam National University Medical School Gwangju Korea) Cheol Min Shin (Department of Internal Medicine Seoul National University Bundang Hospital) Hyun Chul Lim (Department of Internal Medicine Yongin Severance Hospital Yonsei University College of Medicine Yon) Jie-Hyun Kim (Department of Internal Medicine Gangnam Severance Hospital Yonsei University College of Medicine) Su Youn Nam (Division of Gastroenterology Department of Internal Medicine School of Medicine Kyungpook National) Woon Geon Shin (Department of Internal Medicine Hallym University College of Medicine) Jae Myung Park (Department of Gastric Cancer Centre Seoul St. Mary's Hospital The Catholic University of Korea) Il Ju Choi (National Cancer Center) Jae Gyu Kim (Departments of Internal Medicine Chung-Ang University College of Medicine Seoul Korea) Miyoung Choi (National Evidence-Based Healthcare Collaborating Agency) Korean College of Helicobacter and Upper Gastrointesinal Research (Korean College of Helicobacter and Upper Gastrointesinal Research)
저널정보
대한상부위장관 헬리코박터학회 Korean Journal of Helicobacter Upper Gastrointestinal Research Korean Journal of Helicobacter Upper Gastrointestinal Research Vol.21 No.1
발행연도
2021.1
수록면
48 - 58 (11page)

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Background/Aims: The eradication rate of the first-line standard triple therapy (STT) for Helicobacter pylori (H. pylori) infection has decreased since 2000; therefore, other first-line therapies are required. This study was aimed at investigating the efficacy of bismuth- containing quadruple therapy (PBMT) for first-line H. pylori eradication compared to STT, sequential therapy (SQT), and concomitant therapy (CT). Materials and Methods: The Ovid-MEDLINE, Koreamed, EMBASE, KMBASE, and Cochrane Library databases were searched from January 2008 to July 2018. All identified randomized controlled trials (RCTs) comparing PBMT and non-PBMT for first-line H. pylori eradication therapy were included in the final analysis. Results: A total of 3,653 patients from seven RCTs were enrolled. The pooled eradication rates of PBMT by intention-to-treat (ITT) and per-protocol (PP) analyses were 82.1% (95% CI, 68.2~90.8%) and 88.8% (95% CI, 77.1~94.9%), respectively. However, no statistically significant difference was observed in eradication rates of the 10- or 14-day PBMT as compared to 14-day STT, 10-day SQT, and 10-day CT in ITT and PP analyses. PBMT was significantly higher in adverse events than in the other eradication regimens (RR, 1.64; 95% CI, 1.11~2.44). Considerable heterogeneity in adverse events was observed among studies (χ2=88.7; P<0.001, I2=93%). Conclusions: PBMT can be the first-line treatment for H. pylori eradication in Korea when other first-line options, including STT, SQT, or CT, are unavailable due to their high adverse event rates.
#Adverse effects #Bismuth tripotassium dicitrate #Disease eradication #Helicobacter pylori #Meta-analysis

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참고문헌 (34)

참고문헌 신청
Hooi JKY / 2017 / Global prevalence of Helicobacter pylori infection: systematic review and metaanalysis / Gastroenterology 153:420~429 google schola Moss SF / 2007 / Helicobacter and gastric malignancies / Helicobacter 12(Suppl 1):23~30 google schola Kim SG / 2014 / Guidelines for the diagnosis and treatment of Helicobacter pylori infection in Korea, 2013 revised edition / J Gastroenterol Hepatol 29:1371~1386 google schola Sasaki M / 2010 / Changes in 12-year first-line eradication rate of Helicobacter pylori based on triple therapy with proton pump inhibitor, amoxicillin and clarithromycin / J Clin Biochem Nutr 47:53~58 google schola 공은정 / 2014 / Meta-Analysis of First-Line Triple Therapy for Helicobacter pylori Eradication in Korea: Is It Time to Change? / Journal of Korean Medical Science 29(5):704~713 dbpia

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