지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 10 - 21 (12page)
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Purpose: The stability of graft material and membrane is crucial for successful guided bone regeneration. As 3,4-dihydroxy-L-phenylalanine (DOPA) is known to contribute to the adhesiveness of natural mussel adhesive proteins, the aim of this study was to evaluate the biocompatibility and bone regeneration using collagenated synthetic bone graft attached to the collagen membrane with DOPA in the rabbit calvaria model. Materials and Methods: Four circular bone defects of 8 mm diameter were created in the rabbit calvarium. Each defect in the calvarium was randomly allocated to 1) sham control group, 2) bone graft using a particle-type synthetic bone substitute (OP) group, 3) bone graft using collagenated synthetic bone block (OC) group, or 4) bone graft using the collagenated synthetic bone graft attached to collagen membrane with DOPA (OC-DOPA) group. A total of 10 rabbits were sacrificed at either 2 or 8 weeks post-surgery. Results: During histometric analysis, new bone formation in the OC-DOPA group was significantly greater than that in sham control at 8 weeks. On the contrary, there was no statistically significant difference in new bone area (NBA) between OC-DOPA and OC. Histologic analysis revealed infiltrations of inflammatory cells in the OP, OC, and OC-DOPA groups at 2 weeks. At 8 weeks, there were no remarkable inflammatory cells in the OP and OC groups. However, multinucleated giant cells (MNGC) were observed till 8 weeks in the OC-DOPA group.. Conclusion: The collagenated synthetic bone graft attached to the collagen membrane using DOPA showed its potential for guided bone regeneration. However, MNGC were observed until the late healing period.
목차
등록된 정보가 없습니다.
참고문헌 (18)
참고문헌 신청
Hyun-Suk Cha / 2016 / Frequency of bone graft in implant surgery / Maxillofacial Plastic Reconstructive Surgery 38(03):1~4
Wessing B / 2018 / Guided bone regeneration with collagen membranes and particulate graft materials : a systematic review and meta-analysis / Int J Oral Maxillofac Implants 33:87~100
WangHL / 2006 / "PASS"principlesforpredictableboneregeneration / ImplantDent 15:8~17
Trevisiol L / 2012 / Grafting of large mandibular advancement with a collagen-coated bovine bone(Bio-Oss Collagen)in orthognathic surgery / J Craniofac Surg 23:1343~1348
Lee JT / 2020 / Lateral onlay grafting using different combinationsofsoft-typesyntheticblockgraftsandresorbablecollagenmembranes: Anexperimental in vivo study / Clin Oral Implants Res 31:303~314
Wessing B / 2018 / Guided bone regeneration with collagen membranes and particulate graft materials : a systematic review and meta-analysis / Int J Oral Maxillofac Implants 33:87~100
WangHL / 2006 / "PASS"principlesforpredictableboneregeneration / ImplantDent 15:8~17
Trevisiol L / 2012 / Grafting of large mandibular advancement with a collagen-coated bovine bone(Bio-Oss Collagen)in orthognathic surgery / J Craniofac Surg 23:1343~1348
Lee JT / 2020 / Lateral onlay grafting using different combinationsofsoft-typesyntheticblockgraftsandresorbablecollagenmembranes: Anexperimental in vivo study / Clin Oral Implants Res 31:303~314
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