지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.12
- 수록면
- 43 - 56 (14page)
이용수
초록· 키워드
오류제보하기
Purpose: The purpose of this study was to assess the adhesiveness and cytotoxicity of 3, 4-dihydroxyphenylalanine (DOPA), and to evaluate the role of collagen membrane with DOPA in the guided bone regeneration.
Materials and Methods: Peel resistance and cell cytotoxicity test were performed. Four defect types in nine rabbit calvaria were randomly allocated: i) control, ii) membrane, iii) deproteinized porcine bone mineral (DPBM) covered by membrane with DOPA, and iv) DPBM covered by membrane with cyanoacrylate. Animals were sacrificed at 2 (n=4) and 8 weeks (n=5) for microcomputed tomography and histomorphometric analysis. DOPA showed low peel resistance but high cell viability.
Result: Cyanoacrylate and DOPA groups showed significantly higher mineralized tissue volume (MTV) compared to control and membrane groups at 2 weeks (P<0.05). At 8 weeks, DOPA group showed the highest MTV. Significantly higher new bone area was found in DOPA group at 8 weeks (P<0.05). Bone formation increased from 2 to 8 weeks in DOPA group (P<0.05).
Conclusion: DOPA showed high cell viability and in vivo study revealed predictable performance in bone regeneration.
Materials and Methods: Peel resistance and cell cytotoxicity test were performed. Four defect types in nine rabbit calvaria were randomly allocated: i) control, ii) membrane, iii) deproteinized porcine bone mineral (DPBM) covered by membrane with DOPA, and iv) DPBM covered by membrane with cyanoacrylate. Animals were sacrificed at 2 (n=4) and 8 weeks (n=5) for microcomputed tomography and histomorphometric analysis. DOPA showed low peel resistance but high cell viability.
Result: Cyanoacrylate and DOPA groups showed significantly higher mineralized tissue volume (MTV) compared to control and membrane groups at 2 weeks (P<0.05). At 8 weeks, DOPA group showed the highest MTV. Significantly higher new bone area was found in DOPA group at 8 weeks (P<0.05). Bone formation increased from 2 to 8 weeks in DOPA group (P<0.05).
Conclusion: DOPA showed high cell viability and in vivo study revealed predictable performance in bone regeneration.
목차
Introduction
Materials and Methods
Result
Discussion
References
참고문헌 (44)
참고문헌 신청
[학술지(정기간행물)] - Albandar JM / 2005 / Epidemiology and risk factors of periodontal diseases / Dent Clin North Am 49 : 517 ~ 532
[학술지(정기간행물)] - Hämmerle CH / 2003 / Bone augmentation by means of barrier membranes / Periodontol 2000 33 : 36 ~ 53
[학술지(정기간행물)] - McAllister BS / 2007 / Bone augmentation techniques / J Periodontol 78 : 377 ~ 396
[학술지(정기간행물)] - Nannmark U / 2008 / The bone tissue responses to prehydrated and collagenated corticocancellous porcine bone grafts: a study in rabbit maxillary defects / Clin Implant Dent Relat Res 10 : 264 ~ 270
[학술지(정기간행물)] - Kim SH / 2004 / Chemical, structural properties, and osteoconductive effectiveness of bone block derived from porcine cancellous bone / J Biomed Mater Res B Appl Biomater 68 : 69 ~ 74
[학술지(정기간행물)] - Hämmerle CH / 2003 / Bone augmentation by means of barrier membranes / Periodontol 2000 33 : 36 ~ 53
[학술지(정기간행물)] - McAllister BS / 2007 / Bone augmentation techniques / J Periodontol 78 : 377 ~ 396
[학술지(정기간행물)] - Nannmark U / 2008 / The bone tissue responses to prehydrated and collagenated corticocancellous porcine bone grafts: a study in rabbit maxillary defects / Clin Implant Dent Relat Res 10 : 264 ~ 270
[학술지(정기간행물)] - Kim SH / 2004 / Chemical, structural properties, and osteoconductive effectiveness of bone block derived from porcine cancellous bone / J Biomed Mater Res B Appl Biomater 68 : 69 ~ 74
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