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논문 기본 정보

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학술저널
저자정보
백영재 (부산대학교) 김정한 (부산대학교) 송재민 (부산대학교) 윤상용 (부산대학교) 김홍성 (부산대학교) 신상훈 (부산대학교)
저널정보
대한악안면성형재건외과학회 Maxillofacial Plastic Reconstructive Surgery Maxillofacial Plastic Reconstructive Surgery 제38권 제3호
발행연도
2016.3
수록면
1 - 6 (6page)
DOI
10.1186/s40902-016-0060-6

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Background: In guided bone regeneration (GBR) technique, many materials have been used for improving biologicaleffectiveness by adding on membranes. The new membrane which was constructed with chitin-fibroin-hydroxyapatite(CNF/HAP) was compared with a collagen membrane (Bio-Gide®) by means of micro-computed tomography. Methods: Fifty-four rats were used in this study. A critical-sized (8 mm) bony defect was created in the calvaria with atrephine bur. The CNF/HAP membrane was prepared by thermally induced phase separation. In the experimentalgroup (n = 18), the CNF/HAP membrane was used to cover the bony defect, and in the control group (n = 18), aresorbable collagen membrane (Bio-Gide®) was used. In the negative control group (n = 18), no membrane was used. In each group, six animals were euthanized at 2, 4, and 8 weeks after surgery. The specimens were analyzed usingmicro-CT. Results: Bone volume (BV) and bone mineral density (BMD) of the new bone showed significant difference betweenthe negative control group and membrane groups (P < 0.05). However, between two membranes, the difference wasnot significant. Conclusions: The CNF/HAP membrane has significant effect on the new bone formation and has the potential to beapplied for guided bone regeneration.

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