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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.11
- 수록면
- 667 - 685 (19page)
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초록· 키워드
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Objectives: Aim of this study was to evaluate bone regenerative efficacy of a chemically cross-linked porcine collagen membrane (CM) when used in combination with highly soluble biphasic calcium phosphate (BCP).
Materials and methods: Physiochemical properties of the experimental collagen membrane were analyzed. Four circumferential defects with diameter of 8 mm were created in each calvarium of New Zealand white rabbits (n = 10). Defects were randomly allocated to one of following 4 groups: 1) BCP-CM (BCP (20% hydroxyapatite/80% -tricalcium phosphate) covered with the prepared collagen membrane), 2) BCP (only BCP used), 3) CM (only the prepared collagen membrane used), and 4) C (control; only blood clot). After 2 weeks (n = 5) and 8 weeks (n = 5), histologic and histomorphometric analyses were performed.
Results: The experimental collagen membrane exhibited dense and compact structure, relatively high tensile strength and lower degradability. Histologic analyses revealed that new bone increased rapidly at 2 weeks, while defect was preserved at 8 weeks. Histomorphometric analyses revealed that the new bone areas increased in the BCP-grafted groups over 8 weeks, with BCP-CM exhibiting greater total augmented area than that of BCP group both at 2 weeks (27.12 ± 3.99 versus 21.97 ± 2.27 ㎟) and 8 weeks (25.75 ± 1.82 versus 22.48 ± 1.10 ㎟) (P < 0.05).
Conclusions: The experimental collagen membrane successfully preserved localized defect for 8 weeks despite early rapid resorption of BCP. Within the study limitations, combined use of the chemically cross-linked porcine collagen membrane and highly soluble BCP aided localized bone regeneration.
Materials and methods: Physiochemical properties of the experimental collagen membrane were analyzed. Four circumferential defects with diameter of 8 mm were created in each calvarium of New Zealand white rabbits (n = 10). Defects were randomly allocated to one of following 4 groups: 1) BCP-CM (BCP (20% hydroxyapatite/80% -tricalcium phosphate) covered with the prepared collagen membrane), 2) BCP (only BCP used), 3) CM (only the prepared collagen membrane used), and 4) C (control; only blood clot). After 2 weeks (n = 5) and 8 weeks (n = 5), histologic and histomorphometric analyses were performed.
Results: The experimental collagen membrane exhibited dense and compact structure, relatively high tensile strength and lower degradability. Histologic analyses revealed that new bone increased rapidly at 2 weeks, while defect was preserved at 8 weeks. Histomorphometric analyses revealed that the new bone areas increased in the BCP-grafted groups over 8 weeks, with BCP-CM exhibiting greater total augmented area than that of BCP group both at 2 weeks (27.12 ± 3.99 versus 21.97 ± 2.27 ㎟) and 8 weeks (25.75 ± 1.82 versus 22.48 ± 1.10 ㎟) (P < 0.05).
Conclusions: The experimental collagen membrane successfully preserved localized defect for 8 weeks despite early rapid resorption of BCP. Within the study limitations, combined use of the chemically cross-linked porcine collagen membrane and highly soluble BCP aided localized bone regeneration.
목차
ABSTRACT
Ⅰ. Introduction
Ⅱ. Materials and methods
Ⅲ. Results
Ⅳ. Discussion
Ⅴ. CONFLICT OF INTEREST
Ⅵ. AUTHOR CONTRIBUTIONS
참고문헌
참고문헌 (36)
참고문헌 신청
[학술지(정기간행물)] - Hammerle CH / 2003 / Bone augmentation by means of barrier membranes / Periodontol 2000 33 : 36 ~ 53
[학술지(정기간행물)] - Thoma DS / 2009 / Evaluation of a new biodegradable membrane to prevent gingival ingrowth into mandibular bone defects in minipigs / Clin Oral Implants Res 20 : 7 ~ 16
[학술지(정기간행물)] - Simion M / 1994 / A comparative study of the effectiveness of e-PTFE membranes with and without early exposure during the healing period / Int J Periodontics Restorative Dent 14 : 166 ~ 180
[학술지(정기간행물)] - Aaboe M / 1998 / Incomplete bone regeneration of rabbit calvarial defects using different membranes / Clin Oral Implants Res 9 : 313 ~ 320
[학술지(정기간행물)] - Selvig KA / 1992 / Regenerative Surgery of Intrabony Periodontal Defects Using Eptfe Barrier Membranes - Scanning Electron-Microscopic Evaluation of Retrieved Membranes Versus Clinical Healing / J Periodontol 63 : 974 ~ 978
[학술지(정기간행물)] - Thoma DS / 2009 / Evaluation of a new biodegradable membrane to prevent gingival ingrowth into mandibular bone defects in minipigs / Clin Oral Implants Res 20 : 7 ~ 16
[학술지(정기간행물)] - Simion M / 1994 / A comparative study of the effectiveness of e-PTFE membranes with and without early exposure during the healing period / Int J Periodontics Restorative Dent 14 : 166 ~ 180
[학술지(정기간행물)] - Aaboe M / 1998 / Incomplete bone regeneration of rabbit calvarial defects using different membranes / Clin Oral Implants Res 9 : 313 ~ 320
[학술지(정기간행물)] - Selvig KA / 1992 / Regenerative Surgery of Intrabony Periodontal Defects Using Eptfe Barrier Membranes - Scanning Electron-Microscopic Evaluation of Retrieved Membranes Versus Clinical Healing / J Periodontol 63 : 974 ~ 978
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