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논문 기본 정보

자료유형
학술저널
저자정보
Young-Gon Sun (Ph.D. Department of Periodontology School of Dentistry Chonnam National University Gwangju Republic) Myeong-Seop Lim (Postgraduate Student Department of Dental Science Graduate School School of Dentistry Chonnam Natio) Young-Joon Kim (Professor Department of Periodontology School of Dentistry Chonnam National University Gwangju Repu) Jeong-In Choi (Postgraduate Student Department of Periodontology School of Dentistry Chonnam National University G)
저널정보
조선대학교 치의학연구원 Oral Biology Research Oral Biology Research 제46권 제4호
발행연도
2022.12
수록면
171 - 182 (12page)

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Biphasic calcium phosphate (BCP), which is a β-tricalcium phosphate (TCP) and hydroxyapatite (HA) composite, is used mainly as a bone graft material. However, it has recently been used for orthopedic, oral, and maxillofacial surgeries. The use of BCP to produce an absorbable screw and plate to reconstruct fractures has been suggested. Nevertheless, further research on using BCP in the surgical field will be needed. In particular, studies on the physical properties of BCP and in vivo analysis are essential. In this study, TCP and HA were mixed at a ratio of 7:3 and heat-treated to form BCP. Scanning electron microscopy, energy-dispersive X-ray spectroscopy, X-ray diffraction, and an MTT assay were conducted to evaluate the surface characteristics and physical and biological properties of each sample. In addition, BCP was used to produce a screw to be implanted into the mandible of beagles. An analysis of the physical properties of BCP confirmed the intermediate properties between TCP and HA. The cell viability was better with BCP than TCP, and significant differences were observed on days 1 and 3. Histological analysis at eight weeks after inserting the BCP screw into the mandible of beagles revealed osseointegration between the BCP screw and bone. The results showed that BCP had better mechanical properties than TCP and excellent biocompatibility, highlighting its potential clinical use. In addition, according to its processing, BCP may be used to produce screws and plates for fracture repair or as membranes and space-modeling tents for guided bone regeneration.

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