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자료유형
학술저널
저자정보
저널정보
전남대학교 의과학연구소 전남의대학술지 전남의대학술지 제51권 제1호
발행연도
2015.1
수록면
33 - 38 (6page)

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Growth hormone deficiency (GHD) is defined as a serum peak GH concentration <10ng/mL with provocation as tested by a combination of at least two separate tests. Theaim of this study was to compare two standard tests, insulin and levodopa (L-dopa),with a primary focus on specificity and accuracy. Clinical data were collected retrospectivelyfrom a review of 120 children who visited the pediatric endocrine clinic atChonnam National University Hospital for the evaluation of short stature betweenJanuary 2006 and April 2014. Subjects underwent GH provocation tests with insulinand L-dopa. Blood samples were obtained at 0, 15, 30, 45, 60, 90, and 120 min afteradministration, and GH levels were measured. In the insulin test, serial glucose levelswere also checked, closely monitoring hypoglycemia. A total of 83 children (69.2%) werediagnosed with GHD and 37 children (30.8%) were diagnosed with idiopathic short stature(ISS). Peak GH levels were achieved an average of 45 min after the administrationof insulin and L-dopa for both groups. The specificity and accuracy were 78.4% and 93.6%for the insulin test and 29.7% and 79.2% for L-dopa test, respectively. In the ISS group,the cumulative frequency of a GH cutoff value of >10 ng/mL at 120 min was 75.6% afterinsulin stimulation compared with 35.1% after L-dopa stimulation. Considering theseresults, we recommend performing the insulin test first to exclude ISS and then theL-dopa test for the diagnosis of GHD. This way, ISS patients are diagnosed after a singletest, thus reducing hospital days and the burden of undergoing two serial tests.

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