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논문 기본 정보

자료유형
학술저널
저자정보
Lee Na Yeong (The Catholic University of Korea) Kim Sung Eun (Seoul St. Mary’s Hospital College of Medicine The Catholic University of Korea Seoul Korea) Kim Seulki (Eunpyeong St. Mary's Hospital College of Medicine The Catholic University of Korea Seoul Korea) Ahn Moon Bae (Seoul St. Mary’s Hospital College of Medicine The Catholic University of Korea Seoul Korea) Kim Shin Hee (Incheon St. Mary’s Hospital College of Medicine The Catholic University of Korea Incheon Korea) Cho Won Kyoung (St. Vincent’s Hospital College of Medicine The Catholic University of Korea Suwon Korea) Cho Kyoung Soon (Bucheon St. Mary’s Hospital College of Medicine The Catholic University of Korea Bucheon Korea) Jung Min Ho (Yeouido St. Mary’s Hospital College of Medicine The Catholic University of Korea Seoul Korea) Suh Byung-Kyu (Seoul St. Mary’s Hospital College of Medicine The Catholic University of Korea Seoul Korea)
저널정보
대한소아내분비학회 Annals of Pediatirc Endocrinology & Metabolism Annals of Pediatric Endocrinology & Metabolism 제26권 제3호
발행연도
2021.9
수록면
192 - 198 (7page)
DOI
10.6065/apem.2040246.123

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Purpose: The aim of this study is to evaluate the effect of body mass index (BMI) on peak serum growth hormone (GH) level after GH stimulation test in children with short stature.Methods: Data were obtained from retrospective medical record reviews of those who visited the pediatric endocrine clinic at St. Vincent’s Hospital of Catholic University for short stature from January 2010 to June 2019. A total of 115 children (66 boys and 49 girls) whose height was less than the third percentile according to age and sex underwent GH stimulation testing.Results: Of the 115 subjects, 47 were diagnosed with GH deficiency (GHD) and 68 were diagnosed with idiopathic short stature (ISS). In patients with GHD, weight standard deviation score (SDS) (P<0.001) and BMI SDS (P≤0.001) were higher, and free thyroxine (T4) level (P=0.012) was lower than those in the ISS group. In total subjects, peak serum GH level after GH stimulation test showed negative correlations with weight SDS (r=-0.465, P<0.001), BMI SDS (r=-0.398, P<0.001), and thyroid stimulating hormone (r=-0.248, P=0.008) and a positive correlation with free T4 (r=0.326, P<0.001). In multiple regression analysis, BMI SDS (P=0.003) was negatively associated with peak serum GH level in GH stimulation testing after adjusting for age, sex, pubertal status, and type of pharmacological stimulus.Conclusion: The BMI SDS influences peak serum GH level after GH stimulation testing. We should consider BMI factors when interpreting the results of GH stimulation testing.
#Body mass index #Growth hormone #Short stature

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참고문헌 (33)

참고문헌 신청
2000 / Consensus guidelines for the diagnosis and treatment of growth hormone (GH) deficiency in childhood and adolescence: summary statement of the GH Research Society. GH Research Society / J Clin Endocrinol Metab 85:3990~3993 google schola Cappa M / 2003 / Evaluation of growth disorders in the paediatric clinic / J Endocrinol Invest 26:54~63 google schola Iranmanesh A / 1991 / Age and relative adiposity are specific negative determinants of the frequency and amplitude of growth hormone(GH)secretory bursts and the half-life of endogenous GH in healthy men / J Clin Endocrinol Metab 73:1081~1088 google schola Weltman A / 2008 / Effects of continuous versus intermittent exercise, obesity, and gender on growth hormone secretion / J Clin Endocrinol Metab 93:4711~4720 google schola Riedel M / 1995 / Pulsatile growth hormone secretion in normal-weight and obese men : differential metabolic regulation during energy restriction / Metabolism 44:605~610 google schola

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