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논문 기본 정보

자료유형
학술저널
저자정보
Oh Jun Suk (Department of Pediatrics, Konyang University Hospital, Daejeon, Korea) Sohn Beomseok (Department of Radiology and Research Institute of Radiological Science and Center for Clinical Imaging Data Science, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.) Choi Youngha (Department of Pediatrics, Kangwon National University Hospital, Chuncheon, Korea) Song Kyungchul (Department of Pediatrics, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, Korea) Suh Junghwan (Department of Pediatrics, Endocrine Research Institute, Severance Children's Hospital, Yonsei University College of Medicine, Seoul, Korea) Kwon Ahreum (Department of Pediatrics, Endocrine Research Institute, Severance Children's Hospital, Yonsei University College of Medicine, Seoul, Korea) Kim Ho-Seong (Department of Pediatrics, Endocrine Research Institute, Severance Children's Hospital, Yonsei University College of Medicine, Seoul, Korea)
저널정보
대한소아내분비학회 Annals of Pediatirc Endocrinology & Metabolism Annals of Pediatric Endocrinology & Metabolism Vol.29 No.2
발행연도
2024.4
수록면
95 - 101 (7page)
DOI
10.6065/apem.2346052.026

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Purpose: Magnetic resonance imaging (MRI) can be used for assessing the morphology of the pituitary gland in children with short stature. The purposes of this study were: (1) to determine if pituitary volume (PV) can distinguish patients with growth hormone (GH) deficiency from those with idiopathic short stature (ISS), (2) to validate an association between PV and severity of GH deficiency, and (3) to compare PV between good and poor response groups in children with GH deficiency or ISS after 1 year of treatment.Methods: Data were collected from the medical records of 152 children with GH deficiency or ISS who underwent GH stimulation test, sella MRI, and GH treatment for at least 1 year. Estimated PVs were calculated using the formula of an ellipsoid. We compared the PVs in patients with GH deficiency with those of patients with ISS. In addition, we assessed the association between PV and severity of GH deficiency, and we assessed growth response after treatment.Results: No difference was observed in PV between patients with GH deficiency and those with ISS. The severity of the GH deficiency seemed to be associated with PV (<i>P</i>=0.082), and the height of the pituitary gland was associated with severity of GH deficiency (<i>P</i><0.005). The PV in the good response group was less than that of the poor response group in patients with GH deficiency (<i>P</i><0.005), and PV showed no association with responsiveness to GH treatment in patients with ISS (<i>P</i>=0.073).Conclusion: The measurement of PV cannot be used for differential diagnosis between GH deficiency and ISS. In patients with GH deficiency, PV tended to be smaller as the severity of GH deficiency increased, but the difference was not significant. PV may be a good response predictor for GH treatment. Further studies, including a radiomics-based approach, will be helpful in elucidating the clinical implications of pituitary morphology in patients with short stature.

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