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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한소아내분비학회 Annals of Pediatirc Endocrinology & Metabolism Annals of Pediatirc Endocrinology & Metabolism 제24권 제2호
- 발행연도
- 2019.1
- 수록면
- 92 - 98 (7page)
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초록· 키워드
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Recombinant human growth hormone (GH) has been in use for over 30 years, and its indications have gradually expanded from the classical replacement therapy in GH deficiency (GHD) to pharmacological therapy in patients with normal GH secretion. The insulin-like growth factor-I (IGF-I ) is closely GH dependent and is the effector of GH biological actions in peripheral tissues. Since IGF-I has potent mitogenic and antiapoptotic effects, the use of GH, especially outside GHD, has raised safety concern regarding cancer risk. The results of experimental, epidemiological and observational studies are not univocal and a number of biases and confounders affect the interpretation of data. The aim of this review is to critically review the data linking GH therapy during childhood with cancer risk, highlighting strengths and weaknesses of the available evidence.
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등록된 정보가 없습니다.
참고문헌 (69)
참고문헌 신청
Clayton PE / 2011 / Growth hormone, the insulin-like growth factor axis, insulin and cancer risk / Nat Rev Endocrinol 7:11~24
Ranke MB / 2018 / Growth hormone - past, present and future / Nat Rev Endocrinol 14:285~300
LeRoith D / 1995 / Molecular and cellular aspects of the insulin-like growth factor I receptor / Endocr Rev 16:143~163
Le Roith D / 2001 / The somatomedin hypothesis: 2001 / Endocr Rev 22:53~74
Baker J / 1993 / Role of insulin-like growth factors in embryonic and postnatal growth / Cell 75:73~82
Ranke MB / 2018 / Growth hormone - past, present and future / Nat Rev Endocrinol 14:285~300
LeRoith D / 1995 / Molecular and cellular aspects of the insulin-like growth factor I receptor / Endocr Rev 16:143~163
Le Roith D / 2001 / The somatomedin hypothesis: 2001 / Endocr Rev 22:53~74
Baker J / 1993 / Role of insulin-like growth factors in embryonic and postnatal growth / Cell 75:73~82
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