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논문 기본 정보

자료유형
학술저널
저자정보
Yoon Ju Young (Department of Pediatrics Pusan National University Children’s Hospital Yangsan Korea) Cheon Chong Kun (Department of Pediatrics Pusan National University Children's Hospital Yangsan Korea) Lee Jung Hyun (Department of Pediatrics Kosin University College of Medicine Yangsan Korea) Kwak Min Jung (Pusan National University Hospital) Kim Hyun-Ji (Department of Pediatrics Ilsin Christian Hospital Busan Korea) Kim Ye Jin (Department of Pediatrics Inje University Haeundae Paik Hospital Busan Korea) Lee Jeong Eun (Department of Pediatrics Inje University Busan Paik Hospital Busan Korea) Chung Woo Yeong (Inje University Busan Paik Hospital Busan Korea) Kim Jeongyun (LG Chem Ltd. Seoul Korea) Yoo Jae-Ho (Department of Pediatrics Dong-A University Hospital Busan Korea)
저널정보
대한소아내분비학회 Annals of Pediatirc Endocrinology & Metabolism Annals of Pediatric Endocrinology & Metabolism 제27권 제1호
발행연도
2022.3
수록면
37 - 43 (7page)
DOI
10.6065/apem.2142110.055

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Purpose: To investigate growth response in children with either idiopathic short stature (ISS) or growth hormone (GH) deficiency (GHD).Methods: The data of prepubertal GHD or ISS children treated using recombinant human GH were obtained from the LG Growth Study database. GHD children were further divided into partial and complete GHD groups. Growth response and factors predicting growth response after 1 and 2 years of GH treatment were investigated.Results: This study included 692 children (98 with ISS, 443 partial GHD, and 151 complete GHD). After 1 year, changes in height standard deviation score (ΔHt-SDS) were 0.78, 0.83, and 0.96 in ISS, partial GHD, and complete GHD, respectively. Height velocity (HV) was 8.72, 9.04, and 9.52 cm/yr in ISS, partial GHD, and complete GHD, respectively. ΔHt-SDS and HV did not differ among the 3 groups. Higher initial body mass index standard deviation score (BMI-SDS) and midparental height standard deviation score (MPH-SDS) were predictors for better growth response after 1 year in ISS and the partial GHD group, respectively. In the complete GHD group, higher Ht-SDS and BMI-SDS predicted better growth response after 1 year. After 2 years of GH treatment, higher BMI-SDS and MPH-SDS predicted a better growth outcome in the partial GHD group, and higher MPH-SDS was a predictor of good growth response in complete GHD.Conclusion: Clinical characteristics and growth response did not differ among groups. Predictors of growth response differed among the 3 groups, and even in the same group, a higher GH dose would be required when poor response is predicted.

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