지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2022.4
- 수록면
- 359 - 368 (10page)
- DOI
- https://doi.org/10.3803/EnM.2021.1384
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초록· 키워드
오류제보하기
Background: Discontinuing growth hormone (GH) treatment during the transition to adulthood has been associated with adversehealth outcomes in patients with childhood-onset growth hormone deficiency (CO-GHD). This study investigated the metabolicchanges associated with interrupting GH treatment in adolescents with CO-GHD during the transition period.
Methods: This study included 187 patients with CO-GHD who were confirmed to have adult GHD and were treated at six academiccenters in Korea. Data on clinical parameters, including anthropometric measurements, metabolic profiles, and bone mineral density(BMD) at the end of childhood GH treatment, were collected at the time of re-evaluation for GHD and 1 year after treatment resumption.
Results: Most patients (n=182, 97.3%) had organic GHD. The median age at treatment discontinuation and re-evaluation was 15.6and 18.7 years, respectively. The median duration of treatment interruption was 2.8 years. During treatment discontinuation, bodymass index Z-scores and total cholesterol, low-density lipoprotein, and non-high-density lipoprotein (HDL) cholesterol levels increased, whereas fasting glucose levels decreased. One year after GH treatment resumption, fasting glucose levels, HDL cholesterollevels, and femoral neck BMD increased significantly. Longer GH interruption (>2 years, 60.4%) resulted in worse lipid profiles atre-evaluation. The duration of interruption was positively correlated with fasting glucose and non-HDL cholesterol levels after adjusting for covariates.
Conclusion: GH treatment interruption during the transition period resulted in worse metabolic parameters, and a longer interruption period was correlated with poorer outcomes. GH treatment should be resumed early in patients with CO-GHD during the transition period.
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