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논문 기본 정보

자료유형
학술저널
저자정보
Kum Chang Dae (Ajou University School of Medicine) Rho Jung Gi (Ajou University School of Medicine) Park Hong Kyu (Gyeongsang National University Changwon Hospital) Lee Hae Sang (Ajou University School of Medicine) Hwang Jin Soon (Ajou University School of Medicine)
저널정보
대한소아내분비학회 Annals of Pediatirc Endocrinology & Metabolism Annals of Pediatirc Endocrinology & Metabolism 제26권 제1호
발행연도
2021.1
수록면
31 - 37 (7page)

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Purpose: Because small for gestational age (SGA) children who fail to experience catch-up growth have an increased risk of short stature in adulthood, growth hormone (GH) treatment is recommended for effective growth. In this study, we evaluated the effect of GH treatment during the prepubertal period and analyzed for correlation between GH treatment response and clinical factors in SGA children. Methods: A retrospective, single-center study was conducted from 2014 to 2020. A total of 34 prepubertal children of short stature up to 4 years of age and born as SGA were enrolled. We recorded clinical data including birth data, age, weight, height, bone age (BA), and insulin-like growth factor 1 (IGF-1) levels. Results: The mean gestational age and birth weight were 37.50±2.51 weeks and 2,200.00±546.79 g. At the start of GH treatment, the mean chronological age and BA were 5.54±1.73 years and 4.52±1.85 years, respectively. The height standard deviation score (SDS) (-2.47±0.45) and IGF-1 SDS (0.16±1.57) were calculated. Height velocity was 9.43±1.40 cm during the first GH treatment year and 7.63±1.16 cm during the second year (P<0.05). The treatment growth response was positively correlated with young age (P=0.047) and lower BA (P=0.049) at the start of treatment. In multiple regression analysis, IGF-1 SDS change had a significantly positive association with GH treatment response (P=0.045). Conclusion: GH treatment is effective for short stature SGA children who do not experience catch-up growth. Early initiation of GH treatment improved growth outcomes. As IGF-1 SDS is positively correlated with height SDS, IGF-1 monitoring is important during GH treatment of SGA prepubertal children.
#Small for gestational age #Growth Hormone #Short stature #Child

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참고문헌 (35)

참고문헌 신청
Lee PA / 2003 / International Small for Gestational Age Advisory Board consensus development conference statement:management of short children born small for gestational age, April 24-October 1, 2001 / Pediatrics 111(6 Pt 1):1253~1261 google schola Karlberg J / 1995 / Growth in full-term small-for-gestational-age infants : from birth to final height / Pediatr Res 38:733~739 google schola Labarta JI / 2009 / Growth and growth hormone treatment in short stature children born small for gestational age / Pediatr Endocrinol Rev 2009;6 Suppl 6(Suppl 3):350~357 google schola Pierrat V / 2011 / Height at 2 and 5 years of age in children born very preterm : the EPIPAGE study / Arch Dis Child Fetal Neonatal Ed 96:F348~F354 google schola Battaglia FC / 1967 / A practical classification of newborn infants by weight and gestational age / J Pediatr 71:159~163 google schola

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