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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 1 - 16 (16page)
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Use of immune checkpoint inhibitors (ICIs) in hepatocellular carcinoma (HCC) has been partially successful. However, most HCC patients do not respond to immunotherapy. HCC has been shown to induce several immune suppressor mechanisms in patients. These suppressor mechanisms include involvement of myeloid-derived suppressor cells, regulatory T-cells, functionally impaired dendritic cells (DCs), neutrophils, monocytes, and tumor associated macrophages. The accumulation of immunosuppressive cells may lead to an immunosuppressive tumor microenvironment as well as the dense fibrotic stroma which may contribute to immune tolerance. Our laboratory has been investigating different cellular mechanisms of immune suppression in HCC patients. In vitro as well as in vivo studies have demonstrated that abrogation of the suppressor cells enhances or unmasks tumor-specific antitumor immune responses. Two or three effective systemic therapies including ICIs and/or molecular targeted therapies and the addition of innovative combination therapies targeting immune suppressor cells may lead to increased immune recognition with a greater tumor response. We reviewed the literature for the latest research on immune suppressor cells in HCC, and here we provide a comprehensive summary of the recent studies in this field.
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참고문헌 (149)
참고문헌 신청
Korangy F / 2004 / Spontaneous tumor-specific humoral and cellular immune responses to NY-ESO-1 in hepatocellular carcinoma / Clin Cancer Res 10:4332~4341
Mizukoshi E / 2011 / Comparative analysis of various tumor-associated antigenspecific t-cell responses in patients with hepatocellular carcinoma / Hepatology 53:1206~1216
Behboudi S / 2010 / Alpha-fetoprotein specific CD4 and CD8 Tcell responses in patients with hepatocellular carcinoma / World J Hepatol 2:256~260
Behboudi S / 2010 / Cell-mediated immune responses to alpha-fetoprotein and other antigens in hepatocellular carcinoma / Liver Int 30:521~526
Zhang HG / 2007 / Specific CD8(+)T-cell responses to HLA-A2 restricted MAGE-A3p271-279 peptide in hepatocellular carcinoma patients without vaccination / Cancer Immunol Immunother 56:1945~1954
Mizukoshi E / 2011 / Comparative analysis of various tumor-associated antigenspecific t-cell responses in patients with hepatocellular carcinoma / Hepatology 53:1206~1216
Behboudi S / 2010 / Alpha-fetoprotein specific CD4 and CD8 Tcell responses in patients with hepatocellular carcinoma / World J Hepatol 2:256~260
Behboudi S / 2010 / Cell-mediated immune responses to alpha-fetoprotein and other antigens in hepatocellular carcinoma / Liver Int 30:521~526
Zhang HG / 2007 / Specific CD8(+)T-cell responses to HLA-A2 restricted MAGE-A3p271-279 peptide in hepatocellular carcinoma patients without vaccination / Cancer Immunol Immunother 56:1945~1954
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Current Status and Future Direction of Immunotherapy in Hepatocellular Carcinoma: What Do the Data Suggest?
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Recent Advances and Future Directions in Immunotherapeutics for Hepatocellular Carcinoma
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Crosstalk between tumor-associated macrophages and neighboring cells in hepatocellular carcinoma
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Advances in immune checkpoint inhibitors for hepatocellular carcinoma
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Multidisciplinary treatment with immune checkpoint inhibitors for advanced stage hepatocellular carcinoma
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Current Trends and Recent Advances in Diagnosis, Therapy, and Prevention of Hepatocellular Carcinoma
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Independent Risk Factors for Hepatocellular Carcinoma Recurrence after Direct-Acting Antiviral Therapy in Patients with Chronic Hepatitis C
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Current role of proton beam therapy in patients with hepatocellular carcinoma
International Journal of Gastrointestinal Intervention
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Myeloid-derived suppressor cells and immune regulation in cancer
한국실험동물학회 학술발표대회 논문집
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A clinical and pathological update on hepatocellular carcinoma
Journal of Liver Cancer
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Cancer Metabolism as a Mechanism of Treatment Resistance and Potential Therapeutic Target in Hepatocellular Carcinoma
Yonsei Medical Journal
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Prognostic Significance of Hes-1, a Downstream Target of Notch Signaling in Hepatocellular Carcinoma
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