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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한백신학회 Clinical and Experimental Vaccine Research Clinical and Experimental Vaccine Research Vol.9 No.2
- 발행연도
- 2020.1
- 수록면
- 97 - 101 (5page)
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초록· 키워드
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Purpose: The success of foot-and-mouth disease (FMD) serological serosurveillance greatly depends on the FMD vaccine which does not include any non-structural proteins (NSPs) of the FMD virus. Since pure FMD vaccines from NSPs are used with the FMD eradication programs using DIVA (Differentiating Infected from Vaccinated Animals) tests. Apart from the in-vivo test defined in the World Organisation for Animal Health, two different test kits were developed in-process NSP detection purposes. The first test kit was developed in 2010 and the second one has been very recently developed in 2019. Materials and Methods: In this study, the level of NSP has been examined by first-chemiluminescent filtration assisted (FAL)-enzyme-linked immunosorbent assay (ELISA) based in-vitro, in-process test kit for Turkey FMD vaccine antigen samples. A total of 94 samples were used. The critical maximum acceptable levels of NSP were determined after purification stage of samples. Results: As a maximum NSP level, 70 ng NSP for the polyethylene glycol concentrated samples and 30 ng NSP for the vaccine antigen mixture samples were accepted. A mini repeatability study was also performed. The correlation between the NSP, total protein, and 146S particul quantity of samples were analyzed. Conclusion: As a conclusion, the chemiluminescent FAL-ELISA based test kit can be used for the NSP purity level determination of in-process samples.
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참고문헌 (14)
참고문헌 신청
Fry EE / 2005 / The structure of foot-and-mouth disease virus / Curr Top Microbiol Immunol 288:71~101
Kweon CH / 2003 / Development of a foot-and-mouth disease NSP ELISA and its comparison with differential diagnostic methods / Vaccine 21:1409~1414
Grubman MJ / 2004 / Foot-and-mouth disease / Clin Microbiol Rev 17:465~493
Sorensen KJ / 1998 / Differentiation of infection from vaccination in foot-and-mouth disease by the detection of antibodies to the non-structural proteins 3D, 3AB and 3ABC in ELISA using antigens expressed in baculovirus / Arch Virol 143:1461~1476
Brocchi E / 2006 / Comparative evaluation of six ELISAs for the detection of antibodies to the non-structural proteins of foot-and-mouth disease virus / Vaccine 24:6966~6979
Kweon CH / 2003 / Development of a foot-and-mouth disease NSP ELISA and its comparison with differential diagnostic methods / Vaccine 21:1409~1414
Grubman MJ / 2004 / Foot-and-mouth disease / Clin Microbiol Rev 17:465~493
Sorensen KJ / 1998 / Differentiation of infection from vaccination in foot-and-mouth disease by the detection of antibodies to the non-structural proteins 3D, 3AB and 3ABC in ELISA using antigens expressed in baculovirus / Arch Virol 143:1461~1476
Brocchi E / 2006 / Comparative evaluation of six ELISAs for the detection of antibodies to the non-structural proteins of foot-and-mouth disease virus / Vaccine 24:6966~6979
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