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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 87 - 90 (4page)
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초록· 키워드
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Triple-negative breast cancer (TNBC) has a higher risk of death within 5 years of being diagnosed than the other forms of breast cancer. It is the second leading cause of death due to cancer among women. Currently, however, no diagnostic blood-based biomarker exists to identify the early stages of TNBC. To address this point, we utilized a human protein microarray system to identify serum autoantibodies that showed different expression patterns between TNBC and normal serum samples, and identified five autoantibodies showing TNBC-specific expression. Among them, we selected the thioredoxin-like 2 (TXNL2) autoantibody and evaluated its diagnostic relevance by dot blot analysis with the recombinant TXNL2 protein. We demonstrated that the TXNL2 autoantibody showed 2- to 6-fold higher expression in TNBC samples than in normal samples suggesting that serum TXNL2 autoantibodies are potential biomarkers for TNBC.
목차
등록된 정보가 없습니다.
참고문헌 (14)
참고문헌 신청
Perou CM / 2000 / Molecular portraits of human breast tumours / Nature 406:747~752
Kalimutho M / 2015 / Targeted therapies for triple-negative breast cancer: combating a stubborn disease / Trends Pharmacol Sci 36:822~846
Collignon J / 2016 / Triple-negative breast cancer: treatment challenges and solutions / Breast Cancer (Dove Med Press) 8:93~107
Fleisher B / 2016 / Current advances in biomarkers for targeted therapy in triple-negative breast cancer / Breast Cancer (Dove Med Press) 8:183~197
Wahba HA / 2015 / Current approaches in treatment of triplenegative breast cancer / Cancer Biol Med 12:106~116
Kalimutho M / 2015 / Targeted therapies for triple-negative breast cancer: combating a stubborn disease / Trends Pharmacol Sci 36:822~846
Collignon J / 2016 / Triple-negative breast cancer: treatment challenges and solutions / Breast Cancer (Dove Med Press) 8:93~107
Fleisher B / 2016 / Current advances in biomarkers for targeted therapy in triple-negative breast cancer / Breast Cancer (Dove Med Press) 8:183~197
Wahba HA / 2015 / Current approaches in treatment of triplenegative breast cancer / Cancer Biol Med 12:106~116
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