Serum Anti-Gal-3 Autoantibody is a Predictive Marker of the Efficacy of Platinum-Based Chemotherapy against Pulmonary Adenocarcinoma

Yanagita, Kengo; Nagashio, Ryo; Ryuge, Shinichiro; Katono, Ken; Jiang, Shi-Xu; Tsuchiya, Benio; Nakashima, Hiroyasu; Fukuda, Eriko; Goshima, Naoki; Saegusa, Makoto; Satoh, Yukitoshi; Masuda, Noriyuki; Sato, Yuichi

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자료유형: 학술저널

저자정보: Yanagita, Kengo (Department of Applied Tumor Pathology, Graduate School of Medical Sciences, Kitasato University) Nagashio, Ryo (Department of Applied Tumor Pathology, Graduate School of Medical Sciences, Kitasato University) Ryuge, Shinichiro (Department of Respiratory Medicine, School of Medicine, Kitasato University) Katono, Ken (Department of Respiratory Medicine, School of Medicine, Kitasato University) Jiang, Shi-Xu (Department of Pathology, School of Medicine, Kitasato University) Tsuchiya, Benio (Department of Applied Tumor Pathology, Graduate School of Medical Sciences, Kitasato University) Nakashima, Hiroyasu (Department of Thoracic and Cardiovascular Surgery, School of Medicine, Kitasato University) Fukuda, Eriko (Molecular Profiling Research Center for Drug Discovery, National Institute of Advanced Industrial Science and Technology) Goshima, Naoki (Molecular Profiling Research Center for Drug Discovery, National Institute of Advanced Industrial Science and Technology) Saegusa, Makoto (Department of Pathology, School of Medicine, Kitasato University) Satoh, Yukitoshi (Department of Thoracic and Cardiovascular Surgery, School of Medicine, Kitasa) Masuda, Noriyuki Sato, Yuichi

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제16권 제17호

발행연도: 2015.1

수록면: 7,959 - 7,965 (7page)

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Background: Identification of predictive markers for the efficacy of platinum-based chemotherapy is necessary to improve the quality of the life of cancer patients. Materials and Methods: We detected proteins recognized by autoantibodies in pretreated sera from patients with lung adenocarcinoma (AC) evaluated as showing progressive disease (PD) or a partial response (PR) after cisplatin-based chemotherapy by proteomic analysis. Then, the levels of the candidate autoantibodies in the pretreated serum were validated by dot-blot analysis for 22 AC patients who received platinum-based chemotherapy, and the expression of identified proteins was immunohistochemically analyzed in 40 AC biopsy specimens. Results: An autoantibody against galectin-3 (Gal-3) was detected in pretreated sera from an AC patient with PD. Serum IgG levels of anti-Gal-3 autoantibody were significantly higher in patients evaluated with PD than in those with PR and stable disease (SD) (p = 0.0084). Furthermore, pretreated biopsy specimens taken from patients evaluated as showing PD following platinumbased chemotherapy showed a tendency to have a higher positive rate of Gal-3 than those with PR and SD (p = 0.0601). Conclusions: These results suggest that serum IgG levels of anti-Gal-3 autoantibody may be useful to predict the efficacy of platinum-based chemotherapy for patients with lung AC.

#Galectin-3 #autoantibody #lung adenocarcinoma #predictive marker #$2D{beta}$ gel electrophoresis

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Yanagita, Kengo

소속기관 Department of Applied Tumor Pathology, Graduate School of Medical Sciences, Kitasato University