Comparison of Oncoplastic Breast-Conserving Surgery and Breast- Conserving Surgery Alone: A Meta-Analysis

Jun-Ying Chen; Yi-Jie Huang; Liu-Lu Zhang; Ci-Qiu Yang; Kun Wang

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자료유형: 학술저널

저자정보: Jun-Ying Chen (Sun Yat-sen University Cancer Center) Yi-Jie Huang (Guangdong Academy of Medical Sciences) Liu-Lu Zhang (Guangdong Academy of Medical Sciences) Ci-Qiu Yang (Guangdong Academy of Medical Sciences) Kun Wang (Guangdong General Hospital China)

저널정보: 한국유방암학회 Journal of Breast Cancer Journal of Breast Cancer Vol.21 No.3

발행연도: 2018.1

수록면: 321 - 329 (9page)

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Purpose: The use of oncoplastic reconstruction for breastconserving surgery (BCS) extends benefits beyond merely minimizing poor cosmetic results. However, the feasibility and oncological safety of oncoplastic surgery (OPS) are controversial. Methods: This meta-analysis aimed to compare the short-term and long-term oncological outcomes of BCS alone and BCS plus OPS. Relevant studies published before July 2017 in the Embase, the Cochrane Library, PubMed, and Web of Science databases were screened and collected. The meta-analysis was performed using STATA software (Stata Corp.). Results: A total of 3,789 patients from 11 studies were included, with 2,691 patients in the BCS-alone group and 1,098 patients in the BCS plus OPS group. The demographics were similar between both groups, and no significant difference was observed in pathological T and N stages between the two groups. Re-excision was less common (relative risk [RR], 0.66; p=0.009) and the positive-margin rate was lower, but not significantly (RR, 0.83; p=0.191), in the BCS plus OPS group than in the BCS-alone group. The local and distal recurrence rates were similar in both groups. Both disease-free survival (hazard ratio [HR], 1.19; 95% confidence interval [CI], 0.96– 1.49; p=0.112) and overall survival (HR, 1.14; 95% CI, 0.76– 1.69; p=0.527) did not differ between the two groups. Conclusion: A combination of BCS and OPS is preferred over BCS alone for decreasing re-excisions and provides similar long-term survival as BCS alone in patients with breast cancer.

참고문헌 (30)

참고문헌 신청

Fisher B / 2002 / Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer / N Engl J Med 347:1233~1241

Veronesi U / 2002 / Twenty-year follow-up of a randomized study comparing breast-conserving surgery with radical mastectomy for early breast cancer / N Engl J Med 347:1227~1232

Clough KB / 1998 / Cosmetic sequelae after conservative treatment for breast cancer: classification and results of surgical correction / Ann Plast Surg 41:471~481

Clough KB / 2015 / Oncoplastic surgery: pushing the limits of breast-conserving surgery / Breast J 21:140~146

Wanis ML / 2013 / Rate of re-excision after breast-conserving surgery for invasive lobular carcinoma / Am Surg 79:1119~1122

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