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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 992 - 998 (7page)
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This study evaluated the effects of combination treatment with alendronate (ALEN) and hormone therapy (HT) on bone mineral density (BMD) in postmenopausal Korean women. This multicenter, randomized, controlled clinical trial enrolled 344 postmenopausal women with low BMD. The women received HT (0.625 mg/day of conjugated equine estrogen and 2.5 mg/day of medroxyprogesterone acetate) alone or in combination with ALEN (10 mg/day) for 1 year. Changes in BMD and biochemical markers of bone turnover were evaluated. Data from 203 women (HT alone, 99; combination treatment, 104) who completed this study were analyzed. BMD at the lumbar spine and total hip increased significantly in both treatment groups after 1 year. There were no significant differences between HT alone vs. the combination of ALEN and HT in mean BMD increase at the lumbar spine (6.9% vs. 7.9%) and total hip (3.7% vs. 3.8%). Combined therapy suppressed serum osteocalcin and urinary deoxypyridinoline to a greater extent than HT alone. In conclusion, compared to HT alone, combination treatment with ALEN and HT for 1 year did not offer a benefit in BMD in postmenopausal Korean women with low BMD.
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참고문헌 (37)
참고문헌 신청
Khosla S / 2011 / The unitary model for estrogen deficiency and the pathogenesis of osteoporosis : is a revision needed? / J Bone Miner Res 26:441~451
The Writing Group for the PEPI / 1996 / Effects of hormone therapy on bone mineral density: results from the postmenopausal estrogen/progestin interventions (PEPI) trial / JAMA 276:1389~1396
Lindsay R / 2002 / Effect of lower doses of conjugated equine estrogens with and without medroxyprogesterone acetate on bone in early postmenopausal women / JAMA 287:2668~2676
Cummings SR / 2008 / The effects of tibolone in older postmenopausal women / N Engl J Med 359:697~708
Anderson GL / 2004 / Effects of conjugated equine estrogen in postmenopausal women with hysterectomy : the Women’s Health Initiative randomized controlled trial / JAMA 291:1701~1712
The Writing Group for the PEPI / 1996 / Effects of hormone therapy on bone mineral density: results from the postmenopausal estrogen/progestin interventions (PEPI) trial / JAMA 276:1389~1396
Lindsay R / 2002 / Effect of lower doses of conjugated equine estrogens with and without medroxyprogesterone acetate on bone in early postmenopausal women / JAMA 287:2668~2676
Cummings SR / 2008 / The effects of tibolone in older postmenopausal women / N Engl J Med 359:697~708
Anderson GL / 2004 / Effects of conjugated equine estrogen in postmenopausal women with hysterectomy : the Women’s Health Initiative randomized controlled trial / JAMA 291:1701~1712
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