지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
이용수
초록· 키워드
오류제보하기
Background: In a randomized controlled trial, we compared the bone mineral densities (BMDs) and blood markers of bone turnover during short-term treatment of osteoporotic women with bisphosphonate alendronate or bazedoxifene, a selective estrogen receptor modulator. Methods: Ten and eleven patients were randomized to the alendronate and bazedoxifene groups, respectively. BMDs were measured before and after 6 months of treatment. Blood tests were used to measure the levels of osteocalcin (OC), C terminal telopeptide of type I collagen (CTX), vitamin D3, and parathyroid hormone pretreatment and after 3 and 6 months of treatment. The variables were compared statistically. Results: The alendronate group showed decreases in blood levels of both OC and CTX during the study period (P<0.001 and P=0.002, respectively), while the bazedoxifene group had a decrease only in OC levels (P=0.012). After 6 months of treatment, BMDs significantly increased in the alendronate group at multiple bone sites, including the L1?4 lumbar vertebrae, femur trochanter, and total femur. However, there was no significant increase in BMD in the bazedoxifene group. BMDs were not significantly different between the 2 groups. Conclusions: Patients treated with alendronate showed more rapid suppression of markers of bone turnover and higher BMD than those treated with bazedoxifene during a short-term regime. Considering the effects and complications of each medication, the relationship between bone turnover rate and bone quality will need to be investigated in future studies.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Low bone mineral density in children and adolescents with cancer
Annals of Pediatirc Endocrinology & Metabolism
2020 .01
-
Effects of Bazedoxifene/Vitamin D Combination Therapy on Serum Vitamin D Levels and Bone Turnover Markers in Postmenopausal Women with Osteopenia: A Randomized Controlled Trial
대한골대사학회지
2023 .05
-
The Effects of Low-Dose Bisphosphonate Treatment on Bone Mineral Density and Bone Turnover Markers in Elderly Patients With Osteoporosis
Annals of geriatric medicine and research
2016 .01
-
Difference in Bone Mineral Density Change at the Lateral Femoral Cortices according to Administration of Different Bisphosphonate Agents
대한골대사학회지
2016 .01
-
Additive effects of eldecalcitol in poorly responding long-term bisphosphonate treatment for osteoporosis
Osteoporosis and Sarcopenia
2019 .01
-
Changes in bone mineral density in unconscious immobile stroke patients from the acute to chronic phases of brain diseases
Osteoporosis and Sarcopenia
2022 .09
-
Change of Bone Mineral Density and Biochemical Markers of Bone Turnover in Patients on Suppressive Levothyroxine Therapy for Differentiated Thyroid Carcinoma
대한골대사학회지
2015 .01
-
Bone microarchitecture and bone mineral density in Graves’ disease
Osteoporosis and Sarcopenia
2023 .06
-
Relationship between Serum Inflammatory Marker and Bone Mineral Density in Healthy Adults
대한골대사학회지
2016 .01
-
젊은 한국인 여성에서 골밀도와 갑상선 자극호르몬과의 연관성
OSTEOPOROSIS
2015 .01
-
Changes in Bone Metabolism in Young Castrated Male Rats
Yonsei Medical Journal
2016 .01
-
Impact of Artistic Gymnastics on Bone Formation Marker, Density and Geometry in Female Adolescents: ABCD-Growth Study
대한골대사학회지
2019 .01
-
The Relationship between Renal Function and Bone Marrow Density in Healthy Korean Women
대한폐경학회지
2017 .08
-
Effect of Lactobacillus Fermentum as a Probiotic Agent on Bone Health in Postmenopausal Women
대한골대사학회지
2022 .11
-
The Changes of CTX, DPD, Osteocalcin, and Bone Mineral Density During the Postmenopausal Period
Annals of Rehabilitation Medicine
2018 .01
-
Combination Therapy of Raloxifene and Alendronate for Treatment of Osteoporosis in Elderly Women
대한폐경학회지
2017 .01
-
Associations between Dietary Fiber Intake and Bone Mineral Density in Adult Korean Population: Analysis of National Health and Nutrition Examination Survey in 2011
대한골대사학회지
2019 .01
-
Use of Bisphosphonates, Calcium and Vitamin D for Bone Demineralization in Patients with Human Immunodeficiency Virus/Acquired Immune Deficiency Syndrome: A Systematic Review and Meta-Analysis of Clinical Trials
대한골대사학회지
2020 .01
-
Longitudinal Change in Trabecular Bone Score during and after Treatment of Osteoporosis in Postmenopausal Korean Women
대한골대사학회지
2017 .01
-
Effects of Hormone Replacement Therapy on Bone Mineral Density in Korean Adults With Turner Syndrome
Journal of Korean Medical Science
2024 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0