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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한노인병학회 Annals of geriatric medicine and research Annals of geriatric medicine and research Vol.20 No.3
- 발행연도
- 2016.1
- 수록면
- 131 - 136 (6page)
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초록· 키워드
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Background: Osteoporosis is commonly treated with bisphosphonates. These drugs promote osteoclast apoptosis, which suppresses bone resorption. However, the probability of side effects increases with long-term use of bisphosphonates. There are several reports in Asia that show comparable effects between low and conventional doses of bisphosphonates; however, such reports are lacking in Korea. Here, we report a case series of 7 patients with osteoporosis —all women aged over 70 years — who were treated with bisphosphonates administered every other week. Methods: Patients who had been diagnosed with osteoporosis and treated with a less frequent dose of bisphosphonates at a tertiary university hospital from January 2010 to May 2016 were included in this study. Bone mineral density (BMD) was assessed at the baseline and at a 12-month interval after the first administration of low-dose bisphosphonates by using dual-energy X-ray absorptiometry. The bone turnover marker C-terminal telopeptide (CTX) was evaluated at 3, 6, and 12 months after the first administration. Results: After 12 months of treatment with a lower dose of bisphosphonates, BMD increased and CTX levels were suppressed. The mean change in BMD was 4.0% at the lumbar spine, 3.1% at the femur neck, and 1.5% at the total hip; CTX was suppressed by 34% at 3 months, 42% at 6 months, and 44% at the end of the treatment. Conclusion: We found that low-dose bisphosphonate therapy improved BMD and suppressed bone turnover rates in elderly Korean women.
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참고문헌 (31)
참고문헌 신청
Odvina CV / 2005 / Severely suppressed bone turnover: a potential complication of alendronate therapy / J Clin Endocrinol Metab 90:1294~1301
Center JR / 1999 / Mortality after all major types of osteoporotic fracture in men and women: an observational study / Lancet 353:878~882
Cooper C / 1997 / The crippling consequences of fractures and their impact on quality of life / Am J Med 103(2A):12S~17S
Epstein S / 2006 / Update of current therapeutic options for the treatment of postmenopausal osteoporosis / Clin Ther 28:151~173
Hughes DE / 1995 / Bisphosphonates promote apoptosis in murine osteoclasts in vitro and in vivo / J Bone Miner Res 10:1478~1487
Center JR / 1999 / Mortality after all major types of osteoporotic fracture in men and women: an observational study / Lancet 353:878~882
Cooper C / 1997 / The crippling consequences of fractures and their impact on quality of life / Am J Med 103(2A):12S~17S
Epstein S / 2006 / Update of current therapeutic options for the treatment of postmenopausal osteoporosis / Clin Ther 28:151~173
Hughes DE / 1995 / Bisphosphonates promote apoptosis in murine osteoclasts in vitro and in vivo / J Bone Miner Res 10:1478~1487
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