지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 1,386 - 1,394 (9page)
이용수
초록· 키워드
오류제보하기
Purpose: To determine the window of time during which osteoporosis affects the management of spinal surgery and the mechanismof bone metabolism changes in males with osteoporosis by examining changes in bone metabolism in young castrated male rats.
Materials and Methods: A total of 30 Sprague-Dawley rats were randomly allocated into two study groups. Group 1 (control) receiveda sham surgery and Group 2 received bilateral orchiectomy to change bone mineral density (BMD). Serum osteocalcin, alkaline phosphatase (ALP), and collagen type 1 cross-linked C-telopeptide (CTX) were analyzed at postoperative date (POD) 8, 10, and 12 weeks. BMDs were measured using micro computed tomography scans.
Results: Femoral and lumbar BMDs were decreased in the orchiectomy groups. BMDs in the sham and orchiectomy groups showed statistically differences at POD 8, 10, and 12 weeks for the femur (p=0.032, 0.008, 0.008) and lumbar spine (p=0.151, 0.008, 0.008, respectively). Serum osteocalcin, ALP, and CTX decreased gradually; however, N-terminal type 1 procollagen (P1NP) showed a slight increase yet no significant change.
Conclusion: In young castrated male rats, a significant decrease in BMD was observed after orchiectomy due to the mixture of two detrimental factors. Young castrated male rats did not reach peak BMD. Increased bone turnover causes bone resorption to exceed bone formation. This study may contribute to the creation of a valuable model for studies of male osteoporosis and the spinal surgery field.
목차
등록된 정보가 없습니다.
참고문헌 (32)
참고문헌 신청
1991 / Consensus development conference: prophylaxis and treatment of osteoporosis / Am J Med 90:107~110
Nagahama K / 2011 / Does alendronate disturb the healing process of posterior lumbar interbody fusion? A prospective randomized trial / J Neurosurg Spine 14:500~507
Rachner TD / 2011 / Osteoporosis: now and the future / Lancet 377:1276~1287
Ryu SJ / 2011 / Roles of alendronate and simvastatin in prevention of bone loss in ovariectomized rats. / Toxicol Environ Health Sci 3:114~119
박은정 / 2014 / Prevalence of Osteoporosis in the Korean Population Based on Korea National Health and Nutrition Examination Survey (KNHANES), 2008--2011 / Yonsei Medical Journal 55(4):1049~1057
Nagahama K / 2011 / Does alendronate disturb the healing process of posterior lumbar interbody fusion? A prospective randomized trial / J Neurosurg Spine 14:500~507
Rachner TD / 2011 / Osteoporosis: now and the future / Lancet 377:1276~1287
Ryu SJ / 2011 / Roles of alendronate and simvastatin in prevention of bone loss in ovariectomized rats. / Toxicol Environ Health Sci 3:114~119
박은정 / 2014 / Prevalence of Osteoporosis in the Korean Population Based on Korea National Health and Nutrition Examination Survey (KNHANES), 2008--2011 / Yonsei Medical Journal 55(4):1049~1057
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Bone Mineral Density Changes after Orchiectomy using a Scrotal Approach in Rats
Neurospine
2015 .01
-
Low bone mineral density in children and adolescents with cancer
Annals of Pediatirc Endocrinology & Metabolism
2020 .01
-
The Relationship between Renal Function and Bone Marrow Density in Healthy Korean Women
대한폐경학회지
2017 .08
-
Bone microarchitecture and bone mineral density in Graves’ disease
Osteoporosis and Sarcopenia
2023 .06
-
Changes in bone mineral density in unconscious immobile stroke patients from the acute to chronic phases of brain diseases
Osteoporosis and Sarcopenia
2022 .09
-
Analysis of bone in adenine-induced chronic kidney disease model rats
Osteoporosis and Sarcopenia
2021 .12
-
Relationship between Serum Inflammatory Marker and Bone Mineral Density in Healthy Adults
대한골대사학회지
2016 .01
-
The Changes of CTX, DPD, Osteocalcin, and Bone Mineral Density During the Postmenopausal Period
Annals of Rehabilitation Medicine
2018 .01
-
Change of Bone Mineral Density and Relationship to Clinical Parameters in Male Stroke Patients
Annals of Rehabilitation Medicine
2016 .12
-
젊은 한국인 여성에서 골밀도와 갑상선 자극호르몬과의 연관성
OSTEOPOROSIS
2015 .01
-
The Association between Muscle Mass Deficits Estimated from Bioelectrical Impedance Analysis and Lumbar Spine Bone Mineral Density in Korean Adults
대한골대사학회지
2016 .01
-
Correlation Between Duration From Injury and Bone Mineral Density in Individuals With Spinal Cord Injury
Annals of Rehabilitation Medicine
2021 .01
-
Effect of Intermittent Fasting on Glucose Homeostasis and Bone Remodeling in Glucocorticoid-Induced Osteoporosis Rat Model
대한골대사학회지
2021 .11
-
The Vietnam Osteoporosis Study: Rationale and design
Osteoporosis and Sarcopenia
2017 .01
-
Bone mineral density change during adjuvant chemotherapy in pediatric osteosarcoma
Annals of Pediatirc Endocrinology & Metabolism
2015 .01
-
Additive effects of eldecalcitol in poorly responding long-term bisphosphonate treatment for osteoporosis
Osteoporosis and Sarcopenia
2019 .01
-
Change of Bone Mineral Density and Biochemical Markers of Bone Turnover in Patients on Suppressive Levothyroxine Therapy for Differentiated Thyroid Carcinoma
대한골대사학회지
2015 .01
-
Longitudinal Change in Trabecular Bone Score during and after Treatment of Osteoporosis in Postmenopausal Korean Women
대한골대사학회지
2017 .01
-
Associations between Dietary Fiber Intake and Bone Mineral Density in Adult Korean Population: Analysis of National Health and Nutrition Examination Survey in 2011
대한골대사학회지
2019 .01
-
Comparison of Bone Mineral Density and Markers of Bone Turnover in Osteoporotic Women after 6-Month Treatment with Alendronate or Bazedoxifene: A Randomized Controlled Trial
대한골대사학회지
2021 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0