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자료유형
학술저널
저자정보
Hiya Boro (Department of Endocrinology and Metabolism All India Institute of Medical Sciences India) Rakhi Malhotra (Department of Endocrinology and Metabolism All India Institute of Medical Sciences India) Suraj Kubihal (Department of Endocrinology and Metabolism All India Institute of Medical Sciences India) Saurav Khatiwada (Department of Endocrinology and Metabolism All India Institute of Medical Sciences India) Vinay Dogra (Department of Endocrinology and Metabolism All India Institute of Medical Sciences India) Velmurugan Mannar (Department of Endocrinology and Metabolism All India Institute of Medical Sciences India) Ashok Kumar Ahirwar (Department of Biochemistry All India Institute of Medical Sciences India) Vandana Rastogi (Department of Endocrinology and Metabolism All India Institute of Medical Sciences India)
저널정보
대한골다공증학회 Osteoporosis and Sarcopenia Osteoporosis and Sarcopenia Vol.9 No.2
발행연도
2023.6
수록면
1 - 6 (6page)
DOI
10.1016/j.afos.2023.05.001

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Objectives: Graves' disease (GD) is the most common cause of thyrotoxicosis. There are many studies that have evaluated bone mineral density (BMD) in Graves’ disease. However, the strength of a bone also depends on its microarchitecture which can be assessed by various techniques. Trabecular bone score (TBS) is a new method for assessing bone microarchitecture that is non-invasive and easily performed. Methods: The present study was a cross-sectional study that involved 50 patients with active GD and 50 healthy controls. Both groups were subjected to an assessment of biochemical parameters followed by measurement of BMD and TBS on the same dual energy X-ray absorptiometry (DXA) machine. Results: The mean age of patients with active GD (N ¼ 50) was 31.9 ± 10.9 years while that of controls was 31.2 ± 4.9 years (P ¼ 0.640). The female: male ratio was the same for both groups (F ¼ 31, M ¼ 19). The mean lumbar spine BMD, femoral neck BMD, total hip BMD, and distal radius BMD were significantly reduced in GD when compared to that in controls. The mean absolute lumbar spine TBS in GD was 1.263 ± 0.101 while that in controls was 1.368 ± 0.073 (P < 0.001). On multivariate regression analysis, the factors that predicted TBS were serum thyroxine (T4) and L1-L4 BMD. Conclusions: Patients with Graves’ disease had reduced bone density at all sites and degraded micro architecture. Long-term studies are required to understand the pattern of recovery of bone micro architecture after the restoration of euthyroidism.

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