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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한소아내분비학회 Annals of Pediatirc Endocrinology & Metabolism Annals of Pediatirc Endocrinology & Metabolism 제23권 제3호
- 발행연도
- 2018.1
- 수록면
- 136 - 140 (5page)
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초록· 키워드
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Purpose: Many studies have reported that patients with type 1 diabetes have reduced bone mineral density (BMD). We assessed bone status in prepubertal children with type 1 diabetes mellitus (type 1 DM) at initial diagnosis and investigated factors associated with BMD. Methods: Prepubertal children (n=29) with newly diagnosed type 1 diabetes from 2006 to 2014 were included. Dual-energy X-ray absorptiometry measured regional and whole-body composition at initial diagnosis. BMD was compared with healthy controls matched for age, sex, and body mass index (BMI). Results: The mean age of all subjects (16 boys and 13 girls) was 7.58±1.36 years (range, 4.8–11.3 years). Initial mean glycosylated hemoglobin (HbA 1c ) level was 12.2%±1.9%. The mean BMD z-scores of lumbar spine, femur neck, and total body were not significantly different between patients and controls. Three patients (10.3%) had low bone density (total body BMD standard deviation score [SDS] < -2.0). To identify determinants of lumbar spine BMD z-score, multivariate regression analysis was performed with stepwise variable selection of age, pubertal status, BMI SDS, insulin like growth factor-1, and HbA 1c . Only BMI SDS was significantly correlated with lumbar spine BMD z-score (β=0.395, P=0.023). Conclusion: Prepubertal children with newly diagnosed type 1 DM had similar bone mass compared to healthy peers. However, patients with low BMI should be carefully monitored for bone density in type 1 DM.
목차
등록된 정보가 없습니다.
참고문헌 (34)
참고문헌 신청
Eisenbarth GS / 2007 / Update in type 1 diabetes / J Clin Endocrinol Metab 92:2403~2407
Vestergaard P / 2007 / Discrepancies in bone mineral density and fracture risk in patients with type 1 and type 2 diabetes: a meta-analysis / Osteoporos Int 18:427~444
Bachrach LK / 2016 / Bone densitometry in children and adolescents / Pediatrics 138(4)
Leger J / 2006 / Lower bone mineral content in children with type 1 diabetes mellitus is linked to female sex, low insulin-like growth factor type I levels, and high insulin requirement / J Clin Endocrinol Metab 91:3947~3953
Karaguzel G / 2006 / Bone mineral density and alterations of bone metabolism in children and adolescents with type 1 diabetes mellitus / J Pediatr Endocrinol Metab 19:805~814
Vestergaard P / 2007 / Discrepancies in bone mineral density and fracture risk in patients with type 1 and type 2 diabetes: a meta-analysis / Osteoporos Int 18:427~444
Bachrach LK / 2016 / Bone densitometry in children and adolescents / Pediatrics 138(4)
Leger J / 2006 / Lower bone mineral content in children with type 1 diabetes mellitus is linked to female sex, low insulin-like growth factor type I levels, and high insulin requirement / J Clin Endocrinol Metab 91:3947~3953
Karaguzel G / 2006 / Bone mineral density and alterations of bone metabolism in children and adolescents with type 1 diabetes mellitus / J Pediatr Endocrinol Metab 19:805~814
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