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논문 기본 정보

자료유형
학술저널
저자정보
Kim SunYoung (Dream Foret Obstetrics and Gynecology, Jeju, Korea.) Kim Heeyon (Department of Obstetrics and Gynecology, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.Institute of Women’s Life Medical Science, Yonsei University College of Medic) Lee Inha (Institute of Women’s Life Medical Science, Yonsei University College of Medicine, Seoul, Korea.Department of Obstetrics and Gynecology, Gangnam Severance Hospital, Yonsei University College) Choi Euna (Department of Obstetrics and Gynecology, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.Institute of Women’s Life Medical Science, Yonsei University College of Medic) Baek JinKyung (Department of Obstetrics and Gynecology, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.Institute of Women’s Life Medical Science, Yonsei University College of Medic) Lee Jaekyung (Department of Obstetrics and Gynecology, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.Institute of Women’s Life Medical Science, Yonsei University College of Medic) Kim Hae-Rim (Department of Statistics, University of Seoul, Seoul, Korea.) Yun Bo Hyon (Department of Obstetrics and Gynecology, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.Institute of Women’s Life Medical Science, Yonsei University College of Medic) Choi Young Sik (Department of Obstetrics and Gynecology, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.Institute of Women’s Life Medical Science, Yonsei University College of Medic) Seo Seok Kyo (Department of Obstetrics and Gynecology, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.Institute of Women’s Life Medical Science, Yonsei University College of Medic)
저널정보
대한의학회 Journal of Korean Medical Science Journal of Korean Medical Science Vol.39 No.1
발행연도
2024.1
수록면
1 - 14 (14page)
DOI
10.3346/jkms.2024.39.e9

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초록· 키워드

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Background: Turner syndrome (TS) is a common chromosomal abnormality, which is caused by loss of all or part of one X chromosome. Hormone replacement therapy in TS is important in terms of puberty, growth and prevention of osteoporosis however, such a study has never been conducted in Korea. Therefore, the purpose of our study was to determine relationship between the starting age, duration of estrogen replacement therapy (ERT) in TS and develop a hormone replacement protocol suitable for the situation in Korea. Methods: This is retrospective study analyzed the medical records in TS patients treated at the Severance hospital, Yonsei University College of Medicine, Seoul, Korea from 1997 to 2019. Total of 188 subjects who had received a bone density test at least once were included in the study. Korean National Health and Nutrition Examination Survey (KNHANES) was used for achieving bone mineral density (BMD) of normal control group. Student’s t-test, MannWhitney U test, ANOVA and correlation analysis were performed using SPSS 18.0. Results: Each BMD measurement was significantly lower in women with TS than in healthy Korean women. Early start and longer duration of ERT is associated with higher lumbar spine BMD but not femur neck BMD. Femur neck BMD, but not lumbar spine BMD was significantly higher in women with mosaicism than 45XO group. Conclusion: Early onset and appropriate duration of hormone replacement therapy is important for increasing bone mineral density in patients with Turner syndrome. Also, ERT affects differently to TS patients according to mosaicism.
#Turner Syndrome #Estrogen #Hormone Replacement Therapy #Bone Mineral Density #Mosaicism

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