지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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초록· 키워드
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Background: The effects of subclinical hyperthyroidism on bone mineral density (BMD) induced by thyroid-stimulating hormone (TSH) suppression therapy in patients with differentiated thyroid cancer (DTC) remains unclear. We conducted a meta-analysis to determine the influence of TSH suppression therapy on BMD. Methods: We performed a systematic search to identify studies which included BMD measurement of femoral neck, total hip or lumbar spine in patients on TSH suppression therapy for DTC. Main outcome measures were difference of BMD of femoral neck, total hip or lumbar spine measured by dual energy X-ray absorptiometry between patients and controls. Results: A systematic search yielded a total of 11 published controlled cross-sectional studies (including about 571 patients and 836 controls). TSH suppression therapy was associated with the lower BMD of total hip (weighted mean difference [WMD], -0.023; 95% confidence interval [CI], -0.047 to 0.000; P=0.050) and spine (WMD, -0.041; 95% CI, -0.057 to -0.026; P<0.001) in postmenopausal women with DTC, while it was not associated with that in premenopausal women and men with DTC. Conclusions: Although the included studies were limited by small numbers, results suggested possible association between chronic TSH suppression therapy and the lower BMD of spine and total hip in postmenopausal women (but not in premenopausal women and men) with DTC. A large, well-designed study with long-term follow-up would provide further insight into the influence of TSH suppression therapy and loss of BMD.
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참고문헌 (57)
참고문헌 신청
Lim H / 2017 / Trends in thyroid cancer incidence and mortality in the United States, 1974-2013 / JAMA 317:1338~1348
Mirian C / 2018 / Trends in thyroid cancer: retrospective analysis of incidence and survival in Denmark 1980-2014 / Cancer Epidemiol 55:81~87
Tam S / 2018 / Survival in differentiated thyroid cancer: comparing the AJCC cancer staging seventh and eighth editions / Thyroid 28:1301~1310
Mazzaferri EL / 2001 / Clinical review 128: current approaches to primary therapy for papillary and follicular thyroid cancer / J Clin Endocrinol Metab 86:1447~1463
Williams GR / 2018 / Thyroid diseases and bone health / J Endocrinol Invest 41:99~109
Mirian C / 2018 / Trends in thyroid cancer: retrospective analysis of incidence and survival in Denmark 1980-2014 / Cancer Epidemiol 55:81~87
Tam S / 2018 / Survival in differentiated thyroid cancer: comparing the AJCC cancer staging seventh and eighth editions / Thyroid 28:1301~1310
Mazzaferri EL / 2001 / Clinical review 128: current approaches to primary therapy for papillary and follicular thyroid cancer / J Clin Endocrinol Metab 86:1447~1463
Williams GR / 2018 / Thyroid diseases and bone health / J Endocrinol Invest 41:99~109
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