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논문 기본 정보

자료유형
학술저널
저자정보
Mohammad Reza Salamat (Isfahan University of Medical Sciences) Amir Hossein Salamat (Isfahan University of Medical Sciences) Mohsen Janghorbani (Isfahan University)
저널정보
대한내분비학회 Endocrinology and Metabolism Endocrinology and Metabolism Vol.31 No.4
발행연도
2016.1
수록면
547 - 558 (12page)

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Background: We investigated whether there were gender differences in the effect of obesity on bone mineral density (BMD) basedon menopausal status. Methods: We assessed 5,892 consecutive patients 20 to 91 years old who were referred for dual-energy X-ray absorptiometry(DXA) scans. All subjects underwent a standard BMD scan of the hip (total hip and femoral neck) and lumbar spine (L1 to L4) usinga DXA scan and body size assessment. Body mass index was used to categorize the subjects as normal weight, overweight, andobese. Results: BMD was higher in obese and overweight versus normal weight men, premenopausal women, and postmenopausal women. Compared to men ≥50 years and postmenopausal women with normal weight, the age-adjusted odds ratio of osteopenia was0.19 (95% confidence interval [CI], 0.07 to 0.56) and 0.38 (95% CI, 0.29 to 0.51) for obese men ≥50 years and postmenopausalwomen. Corresponding summaries for osteoporosis were 0.26 (95% CI, 0.11 to 0.64) and 0.15 (95% CI, 0.11 to 0.20), respectively. Compared to men <50 years and premenopausal women with normal weight, the age-adjusted odds ratio of low bone mass was 0.22(95% CI, 0.11 to 0.45) and 0.16 (95% CI, 0.10 to 0.26) for obese men <50 years and premenopausal women, respectively. Conclusion: Obesity is associated with BMD of the hip and lumbar spine and overweight and obese individuals have similar degreesof osteoporosis. This result was not significantly different based on gender and menopausal status, which could be an importantissue for further investigation.

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