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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 1 - 9 (9page)
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Background: Brain magnetic resonance imaging (MRI) is routinely performed to identify brain lesions in girls with central precocious puberty (CPP). We aimed to investigate the prevalence and type of brain lesions among Korean girls with CPP and evaluate the need for routine brain MRI examinations. Methods: This retrospective cross-sectional study evaluated data on 3,528 girls diagnosed with CPP from April 2003 to December 2016, and identified 317 girls who underwent sellar MRI. Exclusion criteria were patients with a known brain tumor or who did not undergo brain MRI due to refusal or the decision of the pediatric endocrinologist. Results: Normal sellar MRI findings were observed in 291 of the 317 girls (91.8%). Incidental findings were observed in 26 girls (8.2%). None of the patients had pathological brain lesions. Conclusion: The prevalence of intracranial lesions among girls who were generally healthy and without neurological symptoms but diagnosed with CPP was lower than that previously reported. Furthermore, none of the identified lesions required treatment. It may be prudent to reconsider the routine use of brain MRI to screen all patients with CPP, especially if they are healthy and neurologically asymptomatic, and are girls aged 6–8 years.
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참고문헌 (24)
참고문헌 신청
Kliegman RM / 2016 / Nelson Textbook of Pediatrics / Elsevier
Carel JC / 2009 / Consensus statement on the use of gonadotropin-releasing hormone analogs in children / Pediatrics 123(4):e752~e762
Bridges NA / 1994 / Sexual precocity: sex incidence and aetiology / Arch Dis Child 70(2):116~118
Mogensen SS / 2012 / Pathological and incidental findings on brain MRI in a single-center study of 229 consecutive girls with early or precocious puberty / PLoS One 7(1):e29829
Pedicelli S / 2014 / Routine screening by brain magnetic resonance imaging is not indicated in every girl with onset of puberty between the ages of 6 and 8 years / J Clin Endocrinol Metab 99(12):4455~4461
Carel JC / 2009 / Consensus statement on the use of gonadotropin-releasing hormone analogs in children / Pediatrics 123(4):e752~e762
Bridges NA / 1994 / Sexual precocity: sex incidence and aetiology / Arch Dis Child 70(2):116~118
Mogensen SS / 2012 / Pathological and incidental findings on brain MRI in a single-center study of 229 consecutive girls with early or precocious puberty / PLoS One 7(1):e29829
Pedicelli S / 2014 / Routine screening by brain magnetic resonance imaging is not indicated in every girl with onset of puberty between the ages of 6 and 8 years / J Clin Endocrinol Metab 99(12):4455~4461
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