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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 35 - 40 (6page)
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초록· 키워드
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Objective: The purpose of this study was to evaluate the therapeutic effects of combination therapy with curcumin and alendronate on spine fusion surgery in ovariectomized rats. Methods: Thirty-two female Sprague-Dawley rats (12 weeks old) underwent bilateral ovariectomy (OVX). Eight weeks after surgery, animals underwent intertransverse spine fusion at L4-5. The rats were randomly distributed amongst 4 groups; untreated OVX group, curcumin administered group, alendronate administered group, and the combination therapy group. At 8 weeks after fusion surgery, the animals were sacrificed and the fusion mass was assessed by manual palpation, radiographic scan, and micro-computed tomographic scan. In addition, mechanical strength was determined by a 3-point bending test. Results: Based on the results of manual palpation testing and three-dimensional microcomputed tomography scanning, solid bone fusion rate was 50% (4 of 8) in the OVX group, 75% (6 of 8) in the alendronate-only and curcumin-only group, and 87.5% (7 of 8) in the combination therapy group, respectively. The combination therapy group had a higher fusion rate compared with the other treatment groups, though not statistically significantly (p>0.05). And the combination therapy group had a significant increase in fusion volume at 8 weeks after spine fusion surgery compared with curcumin-only group (p=0.039). The 3-point bending test showed that combination therapy group had a significantly greater maximal load value compared to that of curcumin-only group (p=0.024). Conclusion: The present study demonstrated that additional treatment of curcumin and alendronate after spine fusion surgery in rat can promote higher fusion volume, and improve bone mechanical strength.
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참고문헌 (27)
참고문헌 신청
Abe Y / 2007 / Enhancement of graft bone healing by intermittent administration of human parathyroid hormone (1-34) in a rat spinal arthrodesis model / Bone 41:775~785
Adachi JD / 2001 / The influence of osteoporotic fractures on healthrelated quality of life in community-dwelling men and women across Canada / Osteoporos Int 12:903~908
Babat LB / 2005 / The effects of the antiresorptive agents calcitonin and pamidronate on spine fusion in a rabbit model / Spine J 5:542~547
Bharti AC / 2004 / Curcumin (diferuloylmethane)inhibits receptor activator of NF-kappa B ligand-induced NF-kappa B activation in osteoclast precursors and suppresses osteoclastogenesis / J Immunol 172:5940~5947
조대철 / 2013 / Therapeutic Advantages of Treatment of High-Dose Curcumin in the Ovariectomized Rat / 대한신경외과학회지 54(6):461~466
Adachi JD / 2001 / The influence of osteoporotic fractures on healthrelated quality of life in community-dwelling men and women across Canada / Osteoporos Int 12:903~908
Babat LB / 2005 / The effects of the antiresorptive agents calcitonin and pamidronate on spine fusion in a rabbit model / Spine J 5:542~547
Bharti AC / 2004 / Curcumin (diferuloylmethane)inhibits receptor activator of NF-kappa B ligand-induced NF-kappa B activation in osteoclast precursors and suppresses osteoclastogenesis / J Immunol 172:5940~5947
조대철 / 2013 / Therapeutic Advantages of Treatment of High-Dose Curcumin in the Ovariectomized Rat / 대한신경외과학회지 54(6):461~466
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