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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 413 - 421 (9page)
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초록· 키워드
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Intramuscular fat (IMF) content is an important trait closely related to meat quality, which is highly variable among pig breeds from diverse genetic backgrounds. High-throughput sequencing has become a powerful technique for analyzing the whole transcription profiles of organisms. In order to elucidate the molecular mechanism underlying porcine meat quality, we adopted RNA sequencing to detect transcriptome in the longissimus dorsi muscle of Wei pigs (a Chinese indigenous breed) and Yorkshire pigs (a Western lean-type breed) with different IMF content. For the Wei and Yorkshire pig libraries, over 57 and 64 million clean reads were generated by transcriptome sequencing, respectively. A total of 717 differentially expressed genes (DEGs) were identified in our study (false discovery rate < 0.05 and fold change > 2), with 323 up-regulated and 394 down-regulated genes in Wei pigs compared with Yorkshire pigs. Gene Ontology analysis showed that DEGs significantly related to skeletal muscle cell differentiation, phospholipid catabolic process, and extracellular matrix structural constituent. Pathway analysis revealed that DEGs were involved in fatty acid metabolism, steroid biosynthesis, glycerophospholipid metabolism, and protein digestion and absorption. Quantitative real time PCR confirmed the differential expression of 11 selected DEGs in both pig breeds. The results provide useful information to investigate the transcriptional profiling in skeletal muscle of different pig breeds with divergent phenotypes, and several DEGs can be taken as functional candidate genes related to lipid metabolism (ACSL1, FABP3, UCP3 and PDK4) and skeletal muscle development (ASB2, MSTN, ANKRD1 and ANKRD2).
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등록된 정보가 없습니다.
참고문헌 (42)
참고문헌 신청
Cardoso TF / 2017 / RNA-Seq based detection of differentially expressed genes in the skeletal muscle of Duroc pigs with distinct lipid profiles / Sci Rep 7:40005
Chen Z / 2011 / Association of porcine UCP3 gene polymorphisms with fatness traits in a Pietrain $\times$ Jinhua F2 population / Afr J Biotechnol 10:3296~3300
Wei Chen / 2017 / Longissimus lumborum muscle transcriptome analysis of Laiwu and Yorkshire pigs differing in intramuscular fat content / Genes & Genomics 39(7):759~766
Cho KH / 2011 / Association of genetic variants for FABP3 gene with back fat thickness and intramuscular fat content in pig / Mol Biol Rep 38:2161~2166
Dai FW / 2009 / Developmental differences in carcass, meat quality and muscle fibre characteristics between the Landrace and a Chinese native pig / S Afr J Anim Sci 39:267~273
Chen Z / 2011 / Association of porcine UCP3 gene polymorphisms with fatness traits in a Pietrain
Wei Chen / 2017 / Longissimus lumborum muscle transcriptome analysis of Laiwu and Yorkshire pigs differing in intramuscular fat content / Genes & Genomics 39(7):759~766
Cho KH / 2011 / Association of genetic variants for FABP3 gene with back fat thickness and intramuscular fat content in pig / Mol Biol Rep 38:2161~2166
Dai FW / 2009 / Developmental differences in carcass, meat quality and muscle fibre characteristics between the Landrace and a Chinese native pig / S Afr J Anim Sci 39:267~273
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