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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 462 - 468 (7page)
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Background: Second-generation thyroglobulin immunometric assays (Tg-IMAs) have been developed with improved sensitivity. Our aim was to compare the diagnostic value of Tg-IMA measurements using a Kryptor (BRAHMS AG) kit (Tg-K) and anACCESS (Beckman Coulter) kit (Tg-A) with that of the first-generation Tg measurement using a Tg-plus (BRAHMS AG) kit(Tg+). Methods: We enrolled 82 differentiated thyroid cancer patients who underwent total thyroidectomy with radioactive iodine remnantablation and who underwent diagnostic whole body scan using recombinant human thyroid stimulating hormone (rhTSH). The Tg+, Tg-K, and Tg-A were measured before rhTSH administration during levothyroxine treatment (suppressed Tg) from thesame sample. Serum Tg+ was measured after rhTSH stimulation (stimulated Tg). Results: Suppressed Tg+ was more significantly correlated with suppressed Tg-K (R2=0.919, P<0.001) than with suppressedTg-A (R2=0.536, P<0.001). The optimal cut-off values of suppressed Tg+, Tg-K, and Tg-A for predicting stimulated Tg+ of 1ng/mL were 0.3, 0.2, and 0.2 ng/mL, respectively. The sensitivity, specificity, and accuracy of suppressed Tg+ were 67%, 100%,and 90%, respectively; those of suppressed Tg-K were 83%, 90%, and 88%; those of suppressed Tg-A were 96%, 82%, and 87%,respectively. The positive predictive and negative predictive values of Tg+ were 100% and 87%, respectively; those of Tg-Kwere 79% and 92%; and those of Tg-A were 73% and 98%. Conclusion: We could not clearly demonstrate which kit had better diagnostic performance after comparison of first-generationTg measurements with Tg-IMA measurements. Also, there were kit-to-kit variations between Tg-IMA kits. Suppressed Tg measuredby Tg-IMA was insufficient to completely substitute for a stimulated Tg measurement.
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참고문헌 (25)
참고문헌 신청
Hundahl SA / 1998 / A National Cancer Data Base report on 53,856 cases of thyroid carcinoma treated in the U.S., 1985-1995 see comments / Cancer 83:2638~2648
Tuttle RM / 2010 / Estimating risk of recurrence in differentiated thyroid cancer after total thyroidectomy and radioactive iodine remnant ablation : using response to therapy variables to modify the initial risk estimates predicted by the new American Thyroid Association staging system / Thyroid 20:1341~1349
McGrath RT / 2015 / Is there a role for an ultrasensitive thyroglobulin assay in patients with serum antithyroglobulin antibodies? A large (Australian) cohort study in differentiated thyroid cancer / Clin Endocrinol (Oxf)
Spencer C / 2014 / Serum thyroglobulin(Tg)monitoring of patients with differentiated thyroid cancer using sensitive(second-generation)immunometric assays can be disrupted by false-negative and false-positive serum thyroglobulin autoantibody misclassifications / J Clin Endocrinol Metab 99:4589~4599
American Thyroid Association (ATA) Guidelines Taskforce on Thyroid Nodules and Differentiated Thyroid Cancer / 2009 / Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer / Thyroid 19:1167~1214
Tuttle RM / 2010 / Estimating risk of recurrence in differentiated thyroid cancer after total thyroidectomy and radioactive iodine remnant ablation : using response to therapy variables to modify the initial risk estimates predicted by the new American Thyroid Association staging system / Thyroid 20:1341~1349
McGrath RT / 2015 / Is there a role for an ultrasensitive thyroglobulin assay in patients with serum antithyroglobulin antibodies? A large (Australian) cohort study in differentiated thyroid cancer / Clin Endocrinol (Oxf)
Spencer C / 2014 / Serum thyroglobulin(Tg)monitoring of patients with differentiated thyroid cancer using sensitive(second-generation)immunometric assays can be disrupted by false-negative and false-positive serum thyroglobulin autoantibody misclassifications / J Clin Endocrinol Metab 99:4589~4599
American Thyroid Association (ATA) Guidelines Taskforce on Thyroid Nodules and Differentiated Thyroid Cancer / 2009 / Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer / Thyroid 19:1167~1214
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