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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 72 - 78 (7page)
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Background and Objectives: Prognostic value of additional carotid Doppler evaluations to carotid intima-media thickness (IMT) and plaque has not been completely evaluated. Subjects and Methods: A total of 1119 patients with risk factors for, but without, overt coronary artery disease (CAD), who underwent both carotid ultrasound and Doppler examination were included in the present study. Parameters of interest included peak systolic and end-diastolic velocities, resistive indices of the carotid arteries, IMT, and plaque measurements. The primary end-point was all-cause cerebro-cardiovascular events (CVEs) including acute myocardial infarction, coronary revascularization therapy, heart failure admission, stroke, and cardiovascular death. Model 1 covariates comprised age and sex; Model 2 also included hypertension, diabetes and smoking; Model 3 also had use of aspirin and statin; and Model 4 also included IMT and plaque. Results: The mean follow-up duration was 1386±461 days and the mean age of the study population was 60±12 years. Amongst 1119 participants, 43% were women, 57% had a history of hypertension, and 23% had diabetes. During follow-up, 6.6% of patients experienced CVEs. Among carotid Doppler parameters, average common carotid artery end-diastolic velocity was the independent predictor for future CVEs after adjustments for all models variables (HR 0.95 per cm/s, 95% confident interval 0.91-0.99, p=0.034 inModel 4) and significantly increased the predictive value of Model 4 (global 2=59.0 vs. 62.8, p=0.029). Conclusion: Carotid Doppler measurements in addition to IMT and plaque evaluation are independently associated with future CVEs in asymptomatic patients at risk for CAD.
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참고문헌 (14)
참고문헌 신청
Polak JF / 2011 / Carotid-wall intima–media thickness and cardiovascular events / N Engl J Med 365:213~221
O’Leary DH / 1999 / Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults / N Engl J Med 340:14~22
육형빈 / 2015 / Analysis of Carotid Ultrasound Findings on Cardiovascular Events in Patients with Coronary Artery Disease during Seven-Year Follow-Up / Korean Circulation Journal 45(01):28~37
Grant EG / 2003 / Carotid artery stenosis: grayscale and Doppler US diagnosis--Society of Radiologists in Ultrasound Consensus Conference / Radiology 229:340~346
Bai CH / 2007 / Lower blood flow velocity, higher resistance index, and larger diameter of extracranial carotid arteries are associated with ischemic stroke independently of carotid atherosclerosis and cardiovascular risk factors / J Clin Ultrasound 35:322~330
O’Leary DH / 1999 / Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults / N Engl J Med 340:14~22
육형빈 / 2015 / Analysis of Carotid Ultrasound Findings on Cardiovascular Events in Patients with Coronary Artery Disease during Seven-Year Follow-Up / Korean Circulation Journal 45(01):28~37
Grant EG / 2003 / Carotid artery stenosis: grayscale and Doppler US diagnosis--Society of Radiologists in Ultrasound Consensus Conference / Radiology 229:340~346
Bai CH / 2007 / Lower blood flow velocity, higher resistance index, and larger diameter of extracranial carotid arteries are associated with ischemic stroke independently of carotid atherosclerosis and cardiovascular risk factors / J Clin Ultrasound 35:322~330
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